10 products were found matching "Cay16440"!

U-44069 is a stable analog of the endoperoxide PGH2 (Cay-17020) and a TP receptor agonist. It stimulates shape change in human platelets without a measurable increase in Ca2+ with an EC50 value of 1.8 nM. U-44069 has an EC50 value of 3 µM and 54 nM for platelet aggregation and phosphatidate formation in human...

SET domain-containing protein 8 (SET8) is a methyltransferase that selectively mono-methylates histone H4 at lysine residue 20, an event proven to have an important role in chromatin structure and transcriptional activation. It is also a regulator of p53, mono-methylating lysine 382 of the tumor suppressor. UNC0379...

Lazabemide is an inhibitor of monoamine oxidase B (MAO-B, Ki = 0.084 µM). It is selective for MAO-B over MAO-A (IC50s = 0.02 and 640 µM, respectively). Lazabemide inhibits rat liver MAO-B ex vivo with an ED50 value of 53 nmol/kg. It inhibits ischemia-reperfusion injury-induced hydroxyl radical formation in mouse...

Goat Anti-Human IgE conjugated to SureLight(TM) R-PE, 100µg Antibody: Goat polyclonal Anti-Human IgE Isotype: IgE Uses: Flow cytometry, Fluorescence-activated cell sorting, Luminex, and Protein MicroarraysEmission: 578 nm. Excitation: 565>498 nm. Formulation: (Request formulation change), A lyophilized powder....

JWH 018 (Cay-10900) is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor with Ki values of 9.0 and 2.94 nM for the central cannabinoid (CB1) and CB2 receptors, respectively. CBL-018 is an analog of JWH 018 where the core indole base and the naphthalene group is linked by a carboxylate ester....

TNP-470 is a synthetic analog of fumagillin (Cay-11332) that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2, IC50 = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and...

5-trans U-44069 is the trans isomer of the thromboxane receptor agonist U-44069 (Cay-16440). It inhibits microsomal prostaglandin E2 synthase (mPGES) when used at a concentration of 10 µM.Formal Name: 9,11-dideoxy-9alpha,11alpha-epoxymethano-prosta-5E,13E-dien-1-oic acid. CAS Number: 330796-57-1. Synonyms: 5,6-trans...

SMYD2 is a lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53 and retinoblastoma-associated protein. LLY-507 is a cell-active, small molecule inhibitor of SMYD2 (IC50 = 15 nM). It has been shown to inhibit p53 lysine370 monomethylation in KYSE-150 esophageal squamous...

RU-505 is an inhibitor of the interaction between amyloid-beta (Abeta) and fibrinogen, with a higher efficacy for inhibiting monomeric forms of Abeta bound to fibrinogen over oligomeric forms. In vitro, RU-505 (20 µM) normalizes fibrin clot formation that is disrupted when fibrinogen is bound to Abeta42. RU-505 (35...

19-alkyne Cholesterol is an alkyne derivative of cholesterol (Cay-9003100). It has been used to track cholesterol localization and subcellular distribution in NIH3T3 cells and to study the role of cholesterol in hedgehog (Hh) signal transduction in Shh-LIGHT2 cells using click chemistry and various reporter...