- Search results for Cay16420-%25
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4 products were found matching "Cay16420-%25"!
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Item number: Cay16400-25
SET domain-containing protein 8 (SET8) is a methyltransferase that selectively mono-methylates histone H4 at lysine residue 20, an event proven to have an important role in chromatin structure and transcriptional activation. It is also a regulator of p53, mono-methylating lysine 382 of the tumor suppressor. UNC0379...
Keywords: | 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine |
Application: | SET8 inhibitor |
CAS | 1620401-82-2 |
MW: | 413.6 D |
From 125.00€
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Item number: Cay16480-25
Blonanserin is a 4-phenyl-2-(1-piperazinyl) pyridine that acts as an antagonist at dopamine D2, D3, and serotonin 5-HT2A receptors (Kis = 0.14, 0.49, and 0.81 nM, respectively). It binds to 5-HT6 with a Ki value of 11.7 nM and demonstrates relatively low affinity for 5-HT2C (Ki = 26.4 nM), adrenergic alpha1 (Ki =...
Keywords: | AD5423, Lonasen, 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine |
Application: | 5-HT2A-receptor / dopamine D2-receptor antagonist |
CAS | 132810-10-7 |
MW: | 367.5 D |
From 60.00€
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Item number: Cay16430-25
NSC 146109 is an activator of the tumor suppressor p53 that increases expression of p53 and the p53 target DR5 in wild-type and p53-knockout HCT116 colon adenocarcinoma cells. It is selective for p53, having no effect on p73 expression in HCT116 cells at a concentration of 2 µM. NSC 146109 activates p53, which...
Keywords: | XI-011, carbamimidothioic acid, (10-methyl-9-anthracenyl)methyl ester, monohydrochloride |
Application: | p53 activator |
CAS | 59474-01-0 |
MW: | 316.8 D |
From 98.00€
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Item number: Cay10460-25
The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1. Doramapimod is a highly potent inhibitor of p38 MAPK with a Kd value of 0.1 nM that blocks TNFalpha release in...
Keywords: | BIRB-796, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-urea |
Application: | p38 MAPK inhibitor |
CAS | 285983-48-4 |
MW: | 527.7 D |
From 35.00€
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