9 products were found matching "Cay16420"!
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Prostaglandin F2beta (tromethamine salt)
Item number: Cay16420-10
Prostaglandin F2beta (PGF2beta) (tromethamine salt) is a derivative of PGF2beta (Cay-16410) with increased water solubility. PGF2beta is the 9beta-hydroxy stereoisomer of PGF2alpha (Cay-16010). It is much less active than PGF2alpha in antifertility and bronchoconstrictor activities. PGF2beta exhibits bronchodilating...
| Keywords: | 9beta-PGF2alpha (tromethamine salt), PGF2beta (tromethamine salt), 9beta,11alpha,15S-trihydroxy-prosta-5Z,13E-dien-1-oic... |
| Application: | Bioactive lipid assays |
| CAS | 89847-02-9 |
| MW: | 475.6 D |
From 113.00€
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MA-CHMINACA
Item number: Cay16421-10
AB-CHMINACA (Cay-15434) is an indazole-based synthetic cannabinoid (CB) that is structurally related to AB-FUBINACA (Cay-14039), a high affinity ligand of the CB1 receptor (Ki = 0.9 nM). AB-CHMINACA metabolite M2 is a potential derivative resulting from the replacement of a terminal amide NH2 with a hydroxyl group....
| Keywords: | AMB N-methylcyclohexyl analog, AMB-CHMINACA, MAB-AB-CHMINACA, MMB-CHMINACA,... |
| Application: | Analytical reference standard, Potential synthetic cannabinoid AB-CHMINACA metabolite |
| CAS | 1971007-96-1 |
| MW: | 371.5 D |
From 60.00€
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RVX-208
Item number: Cay16424-10
The bromodomain and extra terminal (BET) proteins interact with acetylated lysine-containing sequences on target proteins via their bromodomains, commonly altering gene transcription. The human BET proteins contain two bromodomains, the first (BD1) being closer to the N-terminus than the second (BD2). RVX-208 is a...
| Keywords: | 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinazolinone |
| Application: | BET bromodomain BD2 antagonist |
| CAS | 1044870-39-4 |
| MW: | 370.4 D |
From 60.00€
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CUDC-101
Item number: Cay16426-10
CUDC-101 is a multi-target inhibitor, combining functional groups of potent inhibitors of human epidermal growth factor receptor (HER) kinases and histone deacetylases (HDACs). It potently blocks the receptor tyrosine kinases EGFR (aka HER1) and HER2 (IC50s = 2.4 and 16.4 nM, respectively). CUDC-101 also inhibits...
| Keywords: | 7-[[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxy-heptanamide |
| Application: | Multi-target (EGFR, HER2, HDAC) inhibitor |
| CAS | 1012054-59-9 |
| MW: | 434.5 D |
From 98.00€
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Darapladib
Item number: Cay16429-10
Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet activating factor acetylhydrolase (PAF-AH) or phospholipase A2 group 7 (PLA2G7), hydrolyzes glycerophospholipids to produce lyso-PAF/lyso-phosphatidylcholine and short and/or oxidized fatty acids, many of which have pro-inflammatory or...
| Keywords: | SB-480848,... |
| Application: | PLA2G7 inhibitor |
| CAS | 356057-34-6 |
| MW: | 666.8 D |
From 66.00€
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PF-04620110
Item number: Cay16425-10
Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides and has potential roles in obesity, diabetes, and atherosclerosis. PF-04620110 is a potent inhibitor of DGAT-1 (IC50 = 19 nM) that is without effect on DGAT-2. It has high oral bioavailability...
| Keywords: | trans-4-[4-(4-amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]-cyclohexaneacetic acid |
| Application: | DGAT1 inhibitor |
| CAS | 1109276-89-2 |
| MW: | 396.4 D |
From 123.00€
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LB 42708
Item number: Cay16428-10
Farnesylation, the post-translational addition of a 15-carbon isoprenyl group, alters the function of several proteins, including Ras proteins. LB 42708 is a potent inhibitor of farnesyltransferase (FTase), blocking farnesylation of H-Ras, N-Ras, and K-Ras4B with IC50 values of 0.8, 1.2, and 2.0 nM, respectively. It...
| Keywords: | [1-[[1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinyl-methanone |
| Application: | FTase inhibitor |
| CAS | 226929-39-1 |
| MW: | 555.5 D |
From 60.00€
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SGI-1776
Item number: Cay16423-10
The Pim family proteins are serine/threonine kinases involved in cancer progression. SGI-1776 is a potent inhibitor of all three human Pim kinases (IC50s = 7, 363, and 69 nM for Pim-1, Pim-2, and Pim-3, respectively). While it also inhibits FLT3 and haspin (IC50s = 44 and 34 nM, respectively), SGI-1776 has little...
| Keywords: | Pim-Kinase Inhibitor IX, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine |
| Application: | Pim1 / Pim2 / Pim3 inhibitor |
| CAS | 1025065-69-3 |
| MW: | 405.4 D |
From 43.00€
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LAQ824
Item number: Cay16427-10
LAQ824 is a hydroxamate-based inhibitor of histone deacetylases (HDACs) with an IC50 value of 30 nM. It inhibits the growth of colon, breast, prostate, and non-small cell lung cancer cell lines at concentrations of less than 1 µM. LAQ824 augments the actions of fludarabine (Cay-14128) and imatinib mesylate...
| Keywords: | Dacinostat, NVP-LAQ824, (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide |
| Application: | HDAC inhibitor |
| CAS | 404951-53-7 |
| MW: | 379.5 D |
From 44.00€
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