16 products were found matching "Cay16300"!

Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes. (±)5-iPF2alpha-VI is one of dozens of possible stereo- and regioisomeric...

Ketamine (hydrochloride) (Cay-11630) is an analytical reference material categorized as an arylcyclohexylamine. Ketamine is a dissociative anesthetic that has been abused recreationally. Ketamine is regulated as a Schedule III compound in the United States. This product is intended for research and forensic...

Streptavidin conjugated to SureLight(TM) APC Binding Moiety: Streptavidin Dye: SureLight(TM) Allophycocyanin (APC) Excitation max. lambda: 652 nm Emission max. lambda: 657.5 nm Uses: Flow cytometry, high-throughput screening (HTS), and fluorescence resonance energy transfer (FRET) assays F:P: 1:1.5Emission: 657.5...

Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis. XL888 is an ATP-competitive inhibitor of Hsp90. Through this action, specific client proteins are degraded, resulting in cell cycle arrest or apoptosis. XL888...

AB-CHMINACA (Cay-15434) is a synthetic cannabinoid (CB) that is an analog of AB-FUBINACA (Cay-14039), a potent agonist of the central CB1 receptor (Ki = 0.9 nM). AB-CHMINACA metabolite M3A is an expected dihydroxylated metabolite produced during metabolism of AB-CHMINACA in the liver. The physiological and...

8-iso-15(R)-Prostaglandin F2alpha (8-iso-15(R) PGF2alpha) is one member of a large family of prostaglandin-like eicosanoids formed by the free radical peroxidation of arachidonic acid in membrane phospholipids. It is the C-15 epimer of 8-iso PGF2alpha, the only isoprostane isomer which has been studied in depth in a...

Ezetimibe is an inhibitor of NPC1-like intracellular cholesterol transporter 1 (NPC1L1, Ki = 220 nM), a cholesterol transporter found in the apical membrane of enterocytes. It reduces cholesterol absorption in hamsters fed a high-cholesterol diet (ED50 = 0.04 mg/kg per day). Ezetimibe (346 nM) also reduces the...

Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA. At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis...

Dihydrolipoic acid (DHLA) is a dithiol-containing carboxylic acid that is the reduced form of alpha-lipoic acid (Cay-10005728). It acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including hydroxyl radicals, peroxynitirite, hydrogen peroxide, and hypochlorite, at...

Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations. It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7alpha-hydroxylase, regulating both xenobiotic and...

Gaboxadol is a GABAA receptor agonist whose potency varies depending on the receptor subunit composition (partial agonist at alpha1beta2gamma2 (ED50 = 143 µM), full agonist at alpha5 (ED50 = 28-129 µM), and super agonist at alpha4beta3delta (ED50 = 6 µM)). It also acts as an antagonist at rho1 GABAC receptors (IC50...

Receptors for AMPA are ionotropic glutamate receptors with critical roles in neurological development and function. Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC50 = 3.8 µM). It blocks the rapid agonist-induced...