10 products were found matching "Cay16290"!

8-iso Prostaglandin F2alpha (8-iso PGF2alpha, 8-isoprostane) is a prostaglandin-like product of non-specific lipid peroxidation. 2,3-dinor-8-iso PGF2alpha is a metabolite of 8-iso PGF2alpha in humans and rats. In these species, exogenously infused 8-iso PGF2alpha is converted to 2,3-dinor-8-iso PGF1alpha and...

TGR5 receptor agonist is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50s = 31.6-158.5 nM in cell-based assays). It stimulates cAMP formation in HEK293 cells expressing TGR5 (EC50 = 2.3 pM). TGR5 receptor agonist (1 mg/kg) increases glucagon-like peptide 1 (GLP-1) secretion and decreases glucose...

Trametinib is an inhibitor of MEK1 and -2. It inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3.4 and 1.8 nM, respectively) and MEK2 (IC50s = 1.6 and 0.92 nM, respectively). Trametinib inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s = 0.48 and 0.52 nM)...

VU0364439 is a positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) that potentiates glutamate responses in CHO cells expressing recombinant human mGluR4 (EC50 = 19.8 nM).Formal Name: N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide. CAS Number: 1246086-78-1....

Metabotropic glutamate receptors (mGluRs) modulate brain excitability through diverse mechanisms. VU0361737 is a selective positive allosteric modulator (PAM) of mGluR4, displaying EC50 values of 110 and 240 nM for rat and human receptors, respectively. It has weak or no activity at other mGluRs. VU0361737 passes...

The recurrent missense mutation T790M in the kinase domain of epidermal growth factor receptor (EGFR) is a gatekeeper mutation, as it sterically hinders binding of inhibitors while preserving catalytic activity. WZ4002 is an irreversible EGFR tyrosine kinase inhibitor that blocks ATP-dependent autophosphorylation of...

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F)....

GIT 27 is an orally active, isoxazole compound that exhibits various immunomodulatory properties both in vitro and in preclinical in vivo models of autoimmune diseases by inhibiting inflammatory antigen presentation. It has been shown to target macrophages, reducing the production of the proinflammatory mediators...

Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. VS-5584 is a purine analog that inhibits mTOR...

XL147 analog 2 is an analog of XL147 (Cay-18011).Formal Name: N-[4-[[[3-[(3,5-dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methyl-benzamide. CAS Number: 1349796-36-6. Molecular Formula: C31H29N5O6S. Formula Weight: 599.7. Purity: >95%. Formulation: (Request formulation change), A...