- Search results for Cay16230
Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
7 products were found matching "Cay16230"!
Close filters
Filter by:
No results were found for the filter!
Item number: Cay16233-10
B-cell lymphoma/leukemia 2 (Bcl-2) is an anti-apoptotic protein that controls cell survival by binding the BH3 domains of pro-death BAD and BAK proteins and preventing permeabilization of the mitochondrial outer membrane. This protein is tightly regulated for the homeostasis between cell growth and cell death. The...
Keywords: | Venetoclax, GDC 0199,... |
Application: | BCL-2 inhibitor |
CAS | 1257044-40-8 |
MW: | 868.4 D |
From 72.00€
*
Item number: Cay16237-10
AZD 9291 is an inhibitor of mutant EGFRs (IC50s = 1, 12, and 5 nM for EGFRL858R/T790M, EGFRL858R, and EGFRL861Q, respectively). It is selective for these mutant EGFRs over wild-type EGFR (IC50 = 184 nM), as well as over a panel of approximately 280 other kinases at 1 µM. AZD 9291 selectively inhibits the...
Keywords: | Osimertinib,... |
Application: | Mutant-selective EGFR inhibitor |
CAS | 1421373-65-0 |
MW: | 499.6 D |
From 43.00€
*
Item number: Cay16239-10
ATP citrate lyase (ACL) catalyzes the synthesis of acetyl-CoA and oxaloacetate using citrate, CoA, and ATP as substrates and Mg2+ as a cofactor. The ACL-dependent synthesis of acetyl-CoA is important for the de novo synthesis of fatty acids and cholesterol. Furthermore, as a key enzyme for linking glucose and lipid...
Keywords: | 3,5-dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide |
Application: | ATP citrate lyase (ACL) inhibitor |
CAS | 943962-47-8 |
MW: | 424.3 D |
From 125.00€
*
Item number: Cay16235-10
AWD 131-138 is a partial agonist of the GABAA receptor that acts at the benzodiazepine binding site, dose-dependently stimulating GABA currents with a threshold of 0.3-1.0 µM. This effect is blocked by the benzodiazepine antagonist flumazenil (Cay-14252). AWD 131-138 displays a broad spectrum of anticonvulsant...
Keywords: | ELB138, Imepitoin, 1-(4-chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one |
Application: | Partial benzodiazepine receptor agonist |
CAS | 188116-07-6 |
MW: | 279.7 D |
From 142.00€
*
Item number: Cay16238-10
BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFbetaR1 (IC50s = 810 and 1,800 nM, respectively). It does not inhibit the closely related kinases MEK1, MEK2, ERK2, and JNK2 (IC50s = > 6,300 nM). BIX02188 inhibits phosphorylation of ERK5 in a...
Keywords: | (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide |
Application: | MEK5 inhibitor |
CAS | 334949-59-6 |
MW: | 412.5 D |
From 60.00€
*
Item number: Cay16231-10
AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and 50 = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis,...
Keywords: | 4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl-1H-pyrazole-3-carboxamide, monohydrochloride |
Application: | CDK inhibitor |
CAS | 902135-91-5 |
MW: | 418.7 D |
From 43.00€
*
Item number: Cay16234-10
ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) that releases hydrogen sulfide (H2S) and a derivative of naproxen (Cay-70290). It inhibits the proliferation of, and induces apoptosis in, A375 melanoma cells when used at a concentration of 100 µM. ATB-346 decreases prostaglandin E2 (PGE2) production in...
Keywords: | 6-methoxy-alpha-methyl-2-naphthaleneacetic acid, 4-(aminothioxomethyl)phenyl ester |
Application: | Antiinflammatory agent |
CAS | 1226895-20-0 |
MW: | 365.5 D |
From 98.00€
*