- Search results for Cay16210
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19 products were found matching "Cay16210"!
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Item number: Cay16210-1
5-trans PGF2alpha is the more thermodynamically stable C-5 olefin isomer of PGF2alpha and is a common impurity in commercial lots of PGF2alpha. 5-trans PGF2alpha administered intravenously to anesthetized rabbits caused a substantial (ten-fold) increase in respiratory rate, but this attribute was common to a number...
Keywords: | 5,6-trans PGF2alpha, 9alpha,11alpha,15S-trihydroxy-prosta-5E,13E-dien-1-oic acid |
Application: | Bioactive lipid assays |
CAS | 36150-01-3 |
MW: | 354.5 D |
From 88.00€
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Item number: Cay11662-10
Pellitorine is an amide alkaloid that has been found in P. nigrum and has diverse biological activities. Pellitorine is cytotoxic to HL-60 leukemia and MCF-7 breast cancer cells (IC50s = 13 and 1.8 µg/ml, respectively). It inhibits production of TNF-alpha, IL-1alpha, and IL-1beta and phosphorylation of ERK1/2...
Keywords: | (2E,4E)-N-(2-methylpropyl)-2,4-decadienamide |
Application: | ACAT inhibitor |
CAS | 18836-52-7 |
MW: | 223.4 D |
From 37.00€
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Item number: Cay16222-100
Pimozide is a dopamine receptor antagonist (Kis = 2.4, 0.3, and 1.8 nM for D2, D3, and D4 receptors, respectively). It also binds to eight additional receptors (Kds = 25-3,100 nM for the human receptors) and inhibits the voltage-gated sodium channel Nav1.2 and the voltage-gated potassium channel Kv11.1 (IC50s = 42...
Keywords: | NSC 170984, R 6238, 1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one |
Application: | Dopamine D2/D3-receptor antagonist |
CAS | 2062-78-4 |
MW: | 461.6 D |
From 43.00€
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Item number: Cay11622-10
Heneicosapentaenoic Acid (HPA) is a fatty acid present in trace amounts in the green algae Bryopsis pennata Lamouroux and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA) except elongated with one carbon on the carboxyl end, placing the first double bond in the Delta6 position. HPA...
Keywords: | HPA methyl ester, 6Z,9Z,12Z,15Z,18Z-heneicosapentaenoic acid, methyl ester |
Application: | Lipid studies |
CAS | 65919-53-1 |
MW: | 330.5 D |
From 145.00€
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Item number: Cay16622-100
Cyproterone acetate (CPA) is an androgen receptor antagonist. It binds to human androgen receptors (Ki = 14 nM) and inhibits dihydrotestosterone-induced androgen receptor activation in CV-1 cells (IC50 = 26 nM). CPA (30 mg/kg) decreases ventral prostate weight in castrated immature rats. It also suppresses accessory...
Keywords: | Androcur(R), CPA, Cyprostat, NSC 81430, SH 714,... |
CAS | 427-51-0 |
MW: | 416.9 D |
From 60.00€
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Item number: Cay16278-10
RKI-1447 is an inhibitor of the Rho-associated kinases ROCK1 and 2 (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2...
Keywords: | N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-urea |
Application: | ROCK inhibitor |
CAS | 1342278-01-6 |
MW: | 326.4 D |
From 82.00€
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Item number: Cay16243-10
CK-636 is an inhibitor of Arp2/3 complex action that binds the complex and inhibits actin polymerization in vitro, using human, bovine and fission yeast proteins (IC50s = 4, 32, and 24 µM, respectively). It is cell permeable, as it prevents actin polymerization and the formation of actin filament comet tails by...
Keywords: | N-[2-(2-methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide |
Application: | Arp2/3 complex inhibitor |
CAS | 442632-72-6 |
MW: | 284.4 D |
From 84.00€
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Item number: Cay16211-10
Phenoxybenzamine is an antagonist of alpha-adrenergic receptors (alpha-ARs). It inhibits norepinephrine-induced inositol phosphate formation in HEK293 cells expressing alpha1-ARs (EC50s = 125.9-316.2 nM), as well as radioligand binding to alpha2A-, alpha2B-, and alpha2C-ARs in CHO cell membranes (Kis = 60, 10, and...
Keywords: | NSC 37448, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine, monohydrochloride |
Application: | alpha2-adrenergic receptor antagonist |
CAS | 63-92-3 |
MW: | 340.3 D |
From 60.00€
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Item number: Cay16240-10
Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell...
Keywords: | XL 139, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-benzamide |
Application: | Smo inhibitor |
CAS | 1059734-66-5 |
MW: | 473.6 D |
From 84.00€
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Item number: Cay16272-10
Jumonji AT-rich interactive domain 1 (JARID1) demethylases mediate the removal of methyl groups from trimethylated lysine 4 on histone 3 (H3K4me3). PBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 µM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively). It...
Keywords: | 2-p-tolyl-1,2-Benzisothiazolin-3-one, 2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one |
Application: | JARID1B inhibitor |
CAS | 2514-30-9 |
MW: | 241.3 D |
From 50.00€
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Item number: Cay16214-10
Benztropine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 0.59 nM in rat brain membranes). It is selective for M1 receptors over the serotonin transporter (Ki = 5,150 nM), however, it also binds to the dopamine transporter and inhibits dopamine reuptake (Kis = 237 and 130 nM, respectively)....
Keywords: | NSC 169913, (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane, monomethanesulfonate |
Application: | Muscarinic cholinergic receptor antagonist |
CAS | 132-17-2 |
MW: | 403.5 D |
From 34.00€
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Item number: Cay16246-10
CYT387 is an ATP-competitive inhibitor of the Janus kinases JAK1 and JAK2 (IC50s = 11 and 18 nM, respectively). It displays significantly less activity against other kinases, including JAK3 (IC50 = 0.16 µM). At 0.5 to 1.5 µM, CYT387 causes growth suppression and apoptosis in JAK2-dependent hematopoietic cell lines....
Keywords: | Momelotinib, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide |
Application: | JAK1 / JAK2 inhibitor |
CAS | 1056634-68-4 |
MW: | 414.5 D |
From 109.00€
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