- Search results for Cay16110
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19 products were found matching "Cay16110"!
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Item number: Cay16110-5
Prostaglandin F2alpha (PGF2alpha) 1,11-lactone is a lipid-soluble internal ester of PGF2alpha. Hydrolysis of the lactone by plasma esterases readily produces free PGF2alpha in rats and monkeys, but not in humans. PGF2alpha 1,11-lactone is active as an antifertility agent with greatly reduced vasoactivity compared to...
Keywords: | PGF2alpha 1,11-lactone, 9alpha,11alpha,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid, 1,11-lactone |
Application: | Bioactive lipid assays |
CAS | 62410-84-8 |
MW: | 336.5 D |
From 117.00€
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Item number: Cay11166-10
5-Azacytidine is an analog of cytidine which can be incorporated into DNA, inhibit DNA methyltransferases, and cause hypomethylation of cytosine residues in the absence of any significant mutagenic effects. Decitabine is a 2'-deoxy analog of 5-azacytidine which similarly causes hypomethylation of DNA by inhibiting...
Keywords: | 5-aza-2'-Deoxycytidine, DAC, NSC 127716, 4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one |
Application: | Cytidine analog |
CAS | 2353-33-5 |
MW: | 228.2 D |
From 64.00€
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Item number: Cay11666-10
Methedrone (4-methoxymethcathinone) is a substituted cathinone with psychoactive actions. Its use as a recreational drug and its toxicity have recently been reported. 4-methyl-N,N-DMC is an analog of methedrone, differing by the presence of a second aminomethyl group. Its biological and toxicological properties have...
Keywords: | 4-methyl-N,N-DMC, N-Methylmethedrone, 2-(dimethylamino)-1-(4-methoxyphenyl)-1-propanone, monohydrochloride |
Application: | Analytical reference standard, Psychoactive substituted cathinone |
CAS | 1089307-23-2 |
MW: | 243.7 D |
From 266.00€
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Item number: Cay16666-100
Monocrotaline is a natural 11-membered macrocyclic pyrrolizidine alkaloid used in an animal model of pulmonary hypertension. It is metabolized by cytochrome P450 3A4 in the liver to monocrotaline pyrrole. Administration of monocrotaline or its metabolite monocrotaline pyrrole to rats causes progressive lung injury...
Keywords: | Crotaline, MCT, NSC 28693,... |
Application: | Pulmonary hypertension inducer |
CAS | 315-22-0 |
MW: | 325.4 D |
From 84.00€
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Item number: Cay11610-200
Amyloid plaques composed primarily of the 42 amino acid form of amyloid-beta peptide (Abeta42) are a hallmark of Alzheimer's disease (AD). However, the roles of the various amyloid beta peptide(s), especially Abeta42, related to the neurotoxicity characteristic of AD remains unclear. A major hindrance to evaluating...
Keywords: | Anti-A4, Anti-C99, Anti-C83, Anti-C80, Anti-C31, Anti-ABPP, Anti-APPI, Anti-CVAP, Anti-PreA4, Anti-PN-II, Anti-N-APP,... |
Application: | ELISA, ICC, IP, WB |
Host: | Mouse |
Species reactivity: | human |
456.00€
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Item number: Cay16100-1
trans-3'-Hydroxycotinine (3HC) is a product of CYP2A6 metabolism of the primary nicotine metabolite, cotinine (Cay-15314). Cotinine has a longer metabolic half-life compared to 3HC (16 hours vs. 5 hours). The ratio of 3HC to cotinine, termed the nicotine metabolite ratio, correlates with nicotine clearance from the...
Keywords: | 3HC, 3R-hydroxy-1-methyl-5S-(3-pyridinyl)-2-pyrrolidinone |
Application: | Nicotine metabolite, CYP2A6 activity biomarker |
CAS | 34834-67-8 |
MW: | 192.2 D |
From 77.00€
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Item number: Cay16610-100
Mouse Anti-HA IgG conjugated to SureLight(TM) APC, 100ug Antibody: Mouse monoclonal Anti-HA (Hemagglutinin) IgG1 Clone: 16B12 Uses: Flow cytometry, cell-based assays, microarrays and microplate applications Spectral Characteristics: Visible absorption maximum = 652 nm Emission maximum = 657.5 nm This monoclonal...
Application: | FC, Cell-based assays, Microarray / microplate applications |
Host: | Mouse |
Species reactivity: | broad |
675.00€
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Item number: Cay16134-10
Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts. Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of...
Keywords: | Clodronic acid, P,P'-(dichloromethylene)bis-phosphonic acid, disodium salt, tetrahydrate |
Application: | Non-nitrogenous bisphosphonate, hydroxyapatite crystal growth inhibitor |
CAS | 88416-50-6 |
MW: | 360.9 D |
From 50.00€
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Item number: Cay16165-10
ISX-9 is a small molecule inducer of adult neural stem cell differentiation both in vitro and in vivo. At 2.5-20 µM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer...
Keywords: | Isoxazole 9, Neuronal Differentiation Inducer III, N-cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide |
Application: | Adult neural stem cell differentiation inducer |
CAS | 832115-62-5 |
MW: | 234.3 D |
From 43.00€
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Item number: Cay16175-10
DOT1L is a non-SET domain containing methyltransferase whose function is important for the transcriptional activation of certain genes, DNA damage repair, and cell cycle regulation. DOT1L is known to play an essential role in MLL-rearranged leukemias, and thus has emerged as a drug target for these leukemias....
Keywords: | 9-[5-deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-beta-D-ribofura... |
Application: | DOT1L inhibitor |
CAS | 1380288-87-8 |
MW: | 562.7 D |
From 60.00€
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Item number: Cay16164-10
Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of...
Keywords: | 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-benzoic acid, propyl ester |
Application: | SMO agonist |
CAS | 300833-95-8 |
MW: | 450.5 D |
From 114.00€
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Item number: Cay16173-10
EPZ004777 is a potent inhibitor of DOT1L (IC50 = 400 pM) that selectively kills mixed lineage leukemia (MLL) cells in vitro and prolongs survival in an MLL xenograft mouse model. It displays >1,000-fold selectivity for DOT1L relative to a panel of histone methyltransferases. DOT1L inhibition by EPZ004777 has also...
Keywords: | 7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-7... |
Application: | DOT1L inhibitor |
MW: | 585.7 D |
From 43.00€
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