15 products were found matching "Cay15910"!

19(R)-hydroxy PGF1alpha is an omega-1 hydroxylase metabolite of PGF1alpha that has been identified in the semen of humans and marsupials. There are no published reports on its biological activity.Formal Name: 9alpha,11alpha,15S,19R-tetrahydroxy-prost-13E-en-1-oic acid. CAS Number: 81371-59-7. Synonyms: 19(R)-hydroxy...

MEK kinases are central components of diverse intracellular signaling pathways. MEK1 and MEK2 specifically act downstream of growth factor receptors and the proto-oncogenes Ras and Raf to activate ERK1 and ERK2, often leading to an increase in cell proliferation. AZD 6244 is a potent, highly selective inhibitor of...

Mdivi 1 is a mitochondrial division inhibitor. It inhibits the GTPase activity of yeast, but not human, dynamin-1 (Dnm1, IC50 = ~1-10 µM for the recombinant yeast enzyme) and human dynamin-related protein 1 (DRP1) in A549 lung cancer cells when used at a concentration of 50 µM. Mdivi 1 (50 µM) inhibits mitochondrial...

Etifoxine is a positive allosteric modulator of alpha1beta2gamma2 and alpha1beta3gamma2 subunit-containing GABAA receptors. It selectively increases GABA-induced currents in X. laevis oocytes expressing alpha1beta2gamma2 or alpha1beta3gamma2 over alpha1beta1gamma2 subunit-containing receptors at 20 µM. Etifoxine...

AKB48 (Cay-ISO00060) is a pentyl indazole with structural similarity to the synthetic cannabinoids (CBs) JWH 018 adamantyl carboxamide (Cay-9001193) and STS-135 (Cay-11564), which have been sold for recreational use. Generally, quinolones with adamantyl-carboxamide moieties display high affinity for the peripheral...

Ritalinic acid is an inactive, major metabolite of methylphenidate (Cay-11639), a schedule II drug in the United States commonly used as a psychostimulant for the treatment of attention-deficit hyperactivity disorder, also known as ADHD. Ritalinic acid is reported to reach plasma concentrations of 1-2 orders of...

5-Cyano-2,3-di-(p-tolyl)tetrazolium (chloride) is a redox-sensitive tetrazolium salt used primarily to detect metabolic activity in microorganisms. This membrane-permeable indicator is readily taken up by living cells and reduced by respiratory activity to produce a red fluorescent, water-insoluble formazan crystal...

Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine (Cay-20822). It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine. Amodiaquine dose-dependently inhibits...

Caspofungin is an echinocandin antifungal originally isolated from G. lozoyensis and a derivative of pneumocandin B0 (Cay-21527). It is active against 3,959 Candida clinical isolates (MIC90 = 1 µg/ml), including isolates resistant to fluconazole (Cay-11594) or itraconazole (Cay-13288), as well as 38 Aspergillus...

The Myc proto-oncogenes interact with Max to form a dimer that regulates gene transcription. The protein c-Myc, in particular, promotes gene expression relevant to cell growth and thus drives cancer. 10058-F4 is a cell-permeable thiazolidinone that inhibits the dimerization of c-Myc and Max at 64 µM, preventing...

Metolazone is a thiazide-like diuretic. It inhibits the Na+/Cl- cotransporter (IC50 = 0.3 µM for the rat transporter) and human carbonic anhydrase VII (CAVII), CAXII, and CAXIII (Kis = 2.1, 5.4, and 15 nM, respectively). Metolazone (0.3 and 1 mg/kg) induces fluid loss and enhances captopril-induced decreases in...

8-bromo Cyclic GMP (8-bromo cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase. At 1 µM-0.1 mM, 8-bromo cGMP can inhibit acetylcholine-induced increases in intracellular...