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SL 327
SL 327

Item number: Cay15598-25

The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 µM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much...
Keywords: alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-benzeneacetonitrile
Application: MEK1 / MEK2 inhibitor
CAS 305350-87-2
MW: 335.4 D
From 77.00€ *
Review
Luzindole
Luzindole

Item number: Cay15998-25

In addition to intrinsic antioxidant activities, melatonin (Cay-14427) evokes its effects through the G protein-coupled receptors MT1A (MT1) and MT1B (MT2). Luzindole is a melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values are = 10-27 and 158-513 nM, respectively). Luzindole is used...
Keywords: N-0774, N-[2-[2-(phenylmethyl)-1H-indol-3-yl]ethyl]-acetamide
Application: Melatonin receptor MTNR1B antagonist
CAS 117946-91-5
MW: 292.3 D
From 84.00€ *
Review