8-iso Prostaglandin F1beta (8-iso PGF1beta) is an isoprostane. It is a potential autooxidation product of the omega-6 fatty acid dihomo-gamma-linolenic acid (DGLA, Cay-90230). 8-iso PGF1beta (10 µM) induces contractions in isolated neonatal porcine pulmonary arteries.Formal Name:...

Transcriptional activation by NF-kappaB is limited by IkappaBalpha binding, which masks the NF-kappaB nuclear localization signal that initiates nuclear translocation. Cytokines trigger a signaling cascade of kinases that target IkappaBalpha for degradation, enabling NF-kappaB to promote gene expression. Because...

Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity. Taurolidine and its metabolites mimic mannose by binding to the extracellular wall of bacteria, blocking adherence to epithelial and fibroblast cells. In addition to...

Butein is a plant polyphenol that is classified as a chalcone, due to the propenone linkage between the phenol groups. Like other polyphenols, butein is a potent antioxidant and affects the numerous pathways modulated by oxidant tone, including inflammation, cancer, and immune response. It inhibits 5-lipoxygenase,...

Arctiin is the major active lignin in fruits of the burdock plant A. lappa. It demonstrates potent antiviral activity against influenza A virus and anti-inflammatory effects by decreasing the production of nitric oxide and pro-inflammatory cytokines. Arctiin is metabolized by human intestinal bacteria into various...