14 products were found matching "Cay15350"!

8-iso Prostaglandin F1alpha (8-iso PGF1alpha) is an isoprostane that was first identified in human semen. It is a member of the isoprostane family, which are eicosanoids of non-cyclooxygenase origin. 8-iso PGF1alpha is present along with its 19-hydroxy congener at 5-10 µg/ml of seminal plasma.Formal Name:...

PV8 (Cay-14762) is an analog of the regulated psychoactive compound alpha-pyrrolidinopentiophenone. 4-fluoro PV8 is a para-fluoro analog of PV8. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.Formal Name:...

Diclofensine is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively. While it has applications as an antidepressant, diclofensine increases locomotor activity, decreases food intake,...

alpha-Pyrrolidinobutiophenone (alpha-PBP, Cay-9001195) is a synthetic cathinone that is related to the regulated stimulant alpha-pyrrolidinopentiophenone (Cay-9001083). alpha-Pyrrolidinobutiothiophenone is an analog of alpha-PBP that has a thiofuran group in place of the phenyl group. The physiological and...

(-)-Cotinine is an alkaloid that has been found in tobacco plants and an active metabolite of the neuronal nicotinic acetylcholine receptor (nAChR) agonists (±)-nicotine (Cay-16535) and (-)-nicotine (Cay-29138, Cay-20887). It is formed from nicotine by the cytochrome P450 (CYP) isoforms CYP2A6 or CYP2A13 via a...

Fibronectin is an extracellular matrix protein which binds other proteins and interacts with cells, serving roles in cell adhesion, migration, and signaling. Like vitronectin and collagen, fibronectin contains a conserved tripeptide sequence, Arg-Gly-Asp (RGD) to associate with integrins on the cell surface. RGDS...

trans-Vaccenic acid is an omega-7 fatty acid that has been found in bovine milk fats. Dietary administration of trans-vaccenic acid (1% w/w) reduces total body fat, mesenteric fat, and adipocyte size, increases inguinal fat mass, and decreases intestinal and hepatic triglyceride secretion in a rat model of obesity...

Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. 20(S)-Ginsenoside Rg3 is a panaxadiol found in white and red P. ginseng. This ginsenoside has diverse in vitro and in vivo...

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. Phortress is a lysyl amide prodrug of the benzothiazole 5-fluoro 203...

The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive...

JIB-04 is a pyridine hydrazone that broadly inhibits Jumonji histone demethylases (IC50s values = 230, 340, 435, 445, 855 and 1,100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3, and JMJD2C, respectively). It does not inhibit histone deacetylases and has minimal effect on the iron-containing enzymes methylcytosine...

SMER3 is a selective inhibitor of Skp1-Cullin-F-box (SCF)MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response. It is a small molecule enhancer of rapamycin (Cay-13346), in that it enhances yeast cell lethality in response to rapamycin. SMER3, at 5 µM, upregulates...