9 products were found matching "Cay15020"!

Prostaglandin F1alpha (PGF1alpha) alcohol is an analog of PGF1alpha with a primary alcohol replacing the C-1 carboxyl group. There are no published reports on the biological activity of this compound, however, the corresponding PGE1 analog (Cay-13020) is a relatively selective EP3 and EP4 receptor ligand.Formal...

Prazosin is an antagonist of alpha1-adrenergic receptors (alpha1-ARs). It selectively binds to alpha1-ARs with Ki values of 0.2, 0.25, and 0.32 nM for the human recombinant alpha1A-, alpha1B-, and alpha1D-ARs, respectively, over alpha2-ARs (Kis = 340 and 3.7 nM in alpha2A-AR-expressing HT-29 cells and...

Sulfasalazine is a prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (Cay-70265) that is covalently linked to the antibiotic sulfapyridine by an azo bond. This bond is rapidly cleaved by bacteria in the terminal ileum and colon, releasing the active anti-inflammatory component. Sulfasalazine (0.1-5...

Tolterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1-5 receptors, respectively). It reduces intracellular calcium mobilization induced by carbachol (carbamoylcholine, Cay-14486) in bladder smooth muscle cells and submandibular gland cells isolated from...

Tigecycline is a broad-spectrum glycylcycline antibiotic that binds to the bacterial 30S ribosome, blocking the entry of transfer RNA, which halts protein synthesis and inhibits bacterial growth. It is active against a panel of 1,924 European clinical bacterial isolates including S. aureus, S. epidermidis, S....

beta-Lapachone is a natural quinone with diverse anti-cancer and anti-inflammatory effects. It inhibits topoisomerase I at 25 µM and transglutaminase (IC50 = 5 µM). In cancer cells which overexpress NAD(P)H:quinone oxidoreductase, beta-lapachone is reduced to beta-lapachone hydroquinone, which generates reactive...

Torcetrapib is an inhibitor of cholesteryl ester transfer protein (CETP, IC50s = 47 and 51 nM for cholesteryl and triglyceride transfer, respectively). It is selective for CETP over phospholipid transfer protein (PLTP), lecithin:cholesterol acyltransferase (LCAT), and hepatic and lipoprotein lipases at 10 µM....

beta-Lactams are a large class of antibiotics that includes penicillins, cephalosporins, carbapenems, and monobactams. Resistance against beta-lactam antibiotics can result from the production of beta-lactamases, which is a common mechanism employed by Gram-negative bacteria. Sulbactam is a penicillanic acid sulfone...

UK 383367 is a potent inhibitor of bone morphogenetic protein 1 (BMP1, IC50 = 44 nM). It is more than 200-fold selective for BMP1 over a panel of matrix metalloproteinases. UK 383367 is effective in a cell-based model of collagen deposition is very effective at penetrating human skin in vitro.Formal Name:...