- Search results for Cay14990
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12 products were found matching "Cay14990"!
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Item number: Cay14990-50
Prostaglandin E3 (PGE3) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid. In human ocular tissue, it comprises 2.4% of the COX products formed. When applied to the eyes of a rabbit, a 1 µg dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.Formal Name:...
Keywords: | PGE3, 9-oxo-11alpha,15S-dihydroxy-prosta-5Z,13E,17Z-trien-1-oic acid |
Application: | Bioactive lipid assays |
CAS | 802-31-3 |
MW: | 350.5 D |
From 189.00€
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Item number: Cay14900-5
Nitracaine is a structural analog of dimethocaine, a local anesthetic that inhibits dopamine reuptake through the dopamine transporter and is characterized by reinforcing behavioral effects in rhesus monkey similar to that of cocaine. The physiological and toxicological properties of this compound are not known....
Keywords: | 3-(diethylamino)-2,2-dimethylpropyl 4-nitrobenzoate |
Application: | Analytical reference standard, Structural dimethocaine analog |
CAS | 1648893-21-3 |
MW: | 308.4 D |
From 84.00€
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Item number: Cay11490-25
Survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important role in drug resistance and cancer cell survival in many types of cancer. YM-155 is a novel small molecule that suppresses transactivation of survivin through direct binding to its promoter. It selectively suppresses expression of...
Keywords: | Sepantronium bromide, 4,9-dihydro-1-(2-methoxyethyl)2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium,... |
Application: | Survivin suppressor |
CAS | 781661-94-7 |
MW: | 443.3 D |
From 48.00€
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Item number: Cay14490-100
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain. These domains function in linking protein complexes to acetylated nucleosomes, thereby controlling chromatin...
Keywords: | L16, ATAD2, ANCCA, ANCCA, ATPase family AAA domain-containing protein 2, ATPase family AAA domain-containing protein 2,... |
Application: | Estrogen and androgen receptor coactivator |
Expressed in: | E.coli |
MW: | 43,1 kD |
481.00€
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Item number: Cay14997-10
Phenformin is an antihyperglycemic biguanide. It reduces blood glucose levels in a mouse model of diabetes induced by alloxan (Cay-9002196) when administered at a dose of 100 mg/kg. Phenformin (250 mg/kg) induces lactic acidosis in diabetic dogs. It also inhibits tumor growth of MCF-7 and MDA-MB-231 breast cancer...
Keywords: | N-(2-phenylethyl)-imidodicarbonimidic diamide, monohydrochloride |
Application: | AMPK activator |
CAS | 834-28-6 |
MW: | 241.7 D |
From 54.00€
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Item number: Cay14998-10
Paroxetine is a selective serotonin reuptake inhibitor (SSRI, Ki = 0.04 nM). It is selective for the serotonin transporter (SERT) over the dopamine and norepinephrine transporters (Kis = 400 and 90 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2A, the histamine H1 receptor,...
Keywords: | BRL 29060A, (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine, monohydrochloride |
Application: | Serotonin reuptake inhibitor |
CAS | 78246-49-8 |
MW: | 365.8 D |
From 66.00€
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Item number: Cay14993-10
Suc-AAPF-pNA is a chromogenic substrate that can be cleaved by cathepsin G (Km = 1.7 mM), subtilisins, chymotrypsin (Km = 60 µM), chymase (Km = 4 mM), and cyclophilin, but not neutrophil elastase. Release of p-nitroanilide is monitored at 405-410 nm. This substrate can be used for inhibitor screening and kinetic...
Keywords: | Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide,... |
Application: | Chromogenic substrate, Inhibitor screening, Kinetic analyses |
CAS | 70967-97-4 |
MW: | 624.7 D |
From 61.00€
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Item number: Cay14995-50
17-trans Prostaglandin E3 (17-trans PGE3) is an isomer of PGE3 which could theoretically result from the COX metabolism of dietary trans-fatty acids. There are no published reports on the biological activity of this compound.Formal Name: 11alpha,15S-dihydroxy-9-oxo-prosta-5Z,13E,17E-trien-1-oic acid. CAS Number:...
Keywords: | 17-trans PGE3, 9-oxo-11alpha,15S-dihydroxy-prosta-5Z,13E,17E-trien-1-oic acid |
Application: | Bioactive lipid assays |
CAS | 210979-33-2 |
MW: | 350.5 D |
From 115.00€
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Item number: Cay14991-10
Ac-LETD-AFC is a fluorogenic substrate that can be cleaved specifically by caspase-8. Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.Formal Name:...
Keywords: | Caspase-8 Substrate (Fluorogenic), N-Acetyl-Leu-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin,... |
Application: | Fluorogenic Caspase-8 substrate |
CAS | 210345-02-1 |
MW: | 729.7 D |
From 85.00€
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Item number: Cay14992-10
Ac-WEHD-AFC is a fluorogenic substrate that can be cleaved by group I caspases (caspase-1, -4, and -5). Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.Formal Name:...
Keywords: | Caspase-1 Substrate (Fluorogenic), Caspase-5 Substrate (Fluorogenic),... |
Application: | Fluorogenic Caspase-1/4/5 substrate |
MW: | 838.7 D |
From 125.00€
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Item number: Cay14999-50
Ondansetron (hydrochloride hydrate) (Cay-14999) is an analytical reference material categorized as an antiemetic. Formulations containing ondansetron have been used to reduce alcohol consumption and mood disturbances in early-onset alcoholics. This product is intended for research and forensic applications.Formal...
Keywords: | Emeset, GR 38032F, NSC 665799, SN 307,... |
Application: | Analytical reference material, Serotonin 5-HT3 receptor antagonist, Antiemetic |
CAS | 103639-04-9 |
MW: | 365.9 D |
From 146.00€
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Item number: Cay14994-250
Metyrapone is an inhibitor of the cytochrome P450 (CYP) enzyme 11beta-hydroxylase (IC50 = 7.83 µM), an enzyme involved in the final step of cortisol biosynthesis. It also induces Cyp1a1 and Cyp3a4 expression in rat hepatic microsomes and inhibits the activity of 11beta-hydroxysteroid dehydrogenase type 1...
Keywords: | NSC 25265, SU 4885, 2-methyl-1,2-di-3-pyridinyl-1-propanone |
Application: | 11beta-hydroxylase inhibitor, CYP450 inhibitor |
CAS | 54-36-4 |
MW: | 226.3 D |
From 34.00€
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