- Search results for Cay14920
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4 products were found matching "Cay14920"!
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Item number: Cay14922-10
Neutrophil elastase is stored within cytoplasmic azurophilic granules in the neutrophil and released upon stimulation by pathogens where it acts either as free protein or is associated with neutrophil extracellular traps (NETs). Together with other proteases released from activated neutrophils, neutrophil elastase...
Keywords: | 1-(3-methylbenzoyl)-1H-indazole-3-carbonitrile |
Application: | ELANE inhibitor |
CAS | 1448314-31-5 |
MW: | 261.3 D |
From 84.00€
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Item number: Cay14921-10
Calpain inhibitor I is a synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). At 10-100 µM calpain inhibitor I dose-dependently prevents the degradation of...
Keywords: | Ac-Leu-Leu-Nle-Aldehyde, ALLN, MG 101, N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-L-leucinamide |
Application: | Cysteine protease inhibitor |
CAS | 110044-82-1 |
MW: | 383.5 D |
From 42.00€
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Item number: Cay14924-10
Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified...
Keywords: | FAK Inhibitor II, Focal Adhesion Kinase Inhibitor II,... |
Application: | PTK2 inhibitor |
CAS | 869288-64-2 |
MW: | 491.5 D |
From 43.00€
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Item number: Cay14926-10
L-685,458 is an inhibitor of gamma-secretase (IC50 = 17 nM). It is selective for gamma-secretase over HIV-1, cathepsin D, trypsin, HepC3 NS3, papain, and calpain I proteases (IC50s = >1,000 nM). L-685,458 inhibits production of amyloid-beta (1-40) (Abeta40, Cay-21617) and Abeta42 (Cay-20574) in Neuro2A cells...
Keywords: | gamma-Secretase Inhibitor X,... |
Application: | gamma-secretase inhibitor |
CAS | 292632-98-5 |
MW: | 672.9 D |
From 245.00€
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