7 products were found matching "Cay14840"!
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tetranor-PGEM
Item number: Cay14840-25
tetranor-Prostaglandin E metabolite (tetranor-PGEM) is the major urinary metabolite of PGE2 (Cay-14010). Urine levels of tetranor-PGEM are increased in patients with diabetic nephropathy. Increased urine levels are also associated with a higher risk of breast cancer in postmenopausal women with a body mass index...
| Keywords: | tetranor-Prostaglandin E Metabolite, 9,15-dioxo-11alpha-hydroxy-13,14-dihydro-2,3,4,5-tetranor-prostan-1,20-dioic acid |
| Application: | Bioactive lipid assays |
| CAS | 24769-56-0 |
| MW: | 328.4 D |
From 179.00€
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Mitoxantrone (hydrochloride)
Item number: Cay14842-10
Mitoxantrone is an inhibitor of DNA topoisomerase IIalpha and HIV-1 integrase (IC50s = 5.3 and 3.8 µM, respectively). It intercalates into DNA in a cell-free assay when used at a concentration of 2 µM, as well as inhibits DNA synthesis and induces DNA-protein crosslinks in vitro in a concentration-dependent manner....
| Keywords: | NCI 301739, NSC 301739, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione, dihydrochloride |
| Application: | Topoisomerase II inhibitor, HIV-1 integrase inhibitor |
| CAS | 70476-82-3 |
| MW: | 517.4 D |
From 43.00€
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ZCL 278
Item number: Cay14849-10
ZCL 278 is a cell-permeable inhibitor of Cdc42, a Rho family GTPase. It binds into the surface groove on Cdc42 (Kd = 6.4-11.4 µM), blocking interaction with intersectin (ITSN), a guanine nucleotide exchange factor (GEF). It inhibits Cdc42-mediated microspike formation and neuronal branching in 3T3 fibroblast and...
| Keywords: | 2-(4-bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]-acetamide |
| Application: | Cdc42 inhibitor |
| CAS | 587841-73-4 |
| MW: | 584.9 D |
From 64.00€
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Galloflavin
Item number: Cay14846-10
Galloflavin is an inhibitor of both the A and B isoforms of lactate dehydrogenase (Kis = 5.46 and 15.06 µM, respectively). It has been shown to prevent proliferation of many different cancer cell lines in vitro by blocking glycolysis and ATP production.Formal Name:...
| Keywords: | NSC 107022, 3,8,9,10-tetrahydroxy-pyrano[3,2-c][2]benzopyran-2,6-dione |
| Application: | LDH inhibitor |
| CAS | 568-80-9 |
| MW: | 278.2 D |
From 50.00€
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HKI 357
Item number: Cay14847-10
HKI 357 is an irreversible dual inhibitor of the EGF receptor tyrosine kinases EGFR and HER2 (IC50s = 34 and 33 nM, respectively). It inhibits proliferation of A431, SK-BR-3, and SW620 cancer cell lines (IC50s = 120, 2.5, and 511 nM, respectively). HKI 357 suppresses EGFR autophosphorylation and phosphorylation of...
| Keywords: | (2E)-N-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide |
| Application: | EGFR inhibitor, HER2 inhibitor |
| CAS | 848133-17-5 |
| MW: | 574.1 D |
From 84.00€
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SA 57
Item number: Cay14848-10
SA 57 is an inhibitor of fatty acid amide hydrolase (FAAH, IC50s = 1.9 and 3.2 nM for hFAAH and mFAAH, respectively), monoacylglycerol lipase (MAGL, IC50s = 1,400 and 410 nM for hMAGL and mMAGL, respectively) and alpha/beta-hydrolase domain-containing protein 6 (mABHD6, IC50 = 850 nM). In vivo, SA 57, at doses >1.25...
| Keywords: | 4-[2-(4-chlorophenyl)ethyl]-1-piperidinecarboxylic acid-2-(methylamino), 2-oxoethyl ester |
| Application: | FAAH inhibitor |
| CAS | 1346169-63-8 |
| MW: | 338.8 D |
From 43.00€
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Sulfaphenazole
Item number: Cay14844-250
CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of various therapeutic agents. Disruption of this enzyme's activity can lead to adverse drug reactions. Sulfaphenazole is an inhibitor of CYP2C9 (Ki = 0.3 µM) that demonstrates at least 100-fold selectivity over other CYP450...
| Keywords: | Depocid, Depotsulfonamide, Plisulfan, Raziosulfa, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-benzenesulfonamide |
| Application: | CYP2C9 inhibitor |
| CAS | 526-08-9 |
| MW: | 314.4 D |
From 158.00€
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