16 products were found matching "Cay14810"!

17-phenyl trinor Prostaglandin E2 (17-phenyl trinor PGE2) is a synthetic analog of PGE2. It is an EP1 and EP3 receptor agonist. 17-phenyl trinor PGE2 causes contraction of the guinea pig ileum at a concentration of 11 µM. It is slightly less potent than PGE2 in stimulating gerbil colon and rat uterus. With an ED50...

4-hydroxy MET (Cay-11148) is an analytical reference standard categorized as a tryptamine. 4-hydroxy MET induces the head-twitch response (HTR) in mice. This product is intended for research and forensic applications.Formal Name: 3-[2-(ethylmethylamino)ethyl]-1H-indol-4-ol. CAS Number: 77872-41-4. Molecular Formula:...

4'-fluoro-alpha-PPP is a derivative of alpha-PPP, characterized by the addition of a fluorine group at the 4 position of the phenyl ring. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.Formal Name:...

Pyronin Y is a fluorescent probe which stains double stranded RNA in living or fixed cells as well as in tissues. When used in living cell preparations, it is commonly combined with 50-100 µM verapamil to prevent efflux of the dye. It has been used to ascertain the cell cycle state of stem cells and is amenable to...

Mitoxantrone is an inhibitor of DNA topoisomerase IIalpha and HIV-1 integrase (IC50s = 5.3 and 3.8 µM, respectively). It intercalates into DNA in a cell-free assay when used at a concentration of 2 µM, as well as inhibits DNA synthesis and induces DNA-protein crosslinks in vitro in a concentration-dependent manner....

1'-Naphthoyl-2-methylindole (Cay-14801) is an analytical reference standard categorized as a precursor in the synthesis of synthetic cannabinoids, including JWH 015 (Cay-10009018), JWH 007 (Cay-10266), JWH 016 (Cay-10859), and JWH 011 (Cay-9001058). This product is intended for research and forensic...

2C-C (Cay-11735) is a 2,5-dimethoxyphenethylamine with a chlorine atom at the four position of the aromatic ring. A known hallucinogen, this compound stimulates monoamine receptor activity while inhibiting the re-uptake of serotonin (Cay-14332) and norepinephrine. 25C-NBOH is a derivative of 2C-C having an...

Marimastat is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 5, 6, 230, 16, and 3 nM for MMP-1, MMP-2, MMP-3, MMP-7, and MMP-9, respectively). It also binds to a recombinantly expressed catalytic domain of human MMP-14 (MMP-14cat, Ki = 2.1 nM) and inhibits gelatinases (IC50s = 3-6 nM), fibroblast...

Ibudilast is an inhibitor of phosphodiesterase 4 (PDE4, IC50s = 54, 65, 239, and 166 nM for PDE4A-D, respectively). It is selective for PDE4 over PDE1, PDE7A, PDE7B, and PDE9A (IC50s = >10,000 nM for all) but does inhibit PDE3A, PDE3B, and PDE5A (IC50s = 1,600, 2,700, and 3,510 nM, respectively). Ibudilast inhibits...

Akt inhibitor VIII is a potent allosteric inhibitor of Akt1 and Akt2 (IC50s = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC50 = 2.2 µM). It is a poor or ineffective inhibitor of a wide range of other serine-threonine kinases. Akt inhibitor VIII is cell permeable, blocking insulin...

HA-14-1 is a small molecule that binds the surface pocket of Bcl-2 proteins (IC50 = ~ 9 µM) and induces apoptosis by interfering with its interaction with the Bak peptide and activating Apaf-1 and caspase-9 and -3. It can also bind to the antiapoptotic Bcl-2 proteins Bcl-xl and Bcl-W. HA-14-1 has been shown to...

Gemfibrozil is a peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma agonist (EC50s = 193.3 and 147.8 µM, respectively, in transactivation assays). In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol...