7 products were found matching "Cay14570"!

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11-deoxy-16,16-dimethyl Prostaglandin E2
11-deoxy-16,16-dimethyl Prostaglandin E2

Item number: Cay14570-10

11-deoxy-16,16-dimethyl Prostaglandin E2 (11-deoxy-16,16-dimethyl PGE2) is a stable synthetic analog of PGE2. It is an agonist for both EP2 and EP3 receptors. It is an effective inhibitor of gastric acid secretion and ulcer formation in the rat, with ED50 values of 1 mg/kg and 0.021 mg/kg respectively. It is 900...
Keywords: 11-deoxy-16,16-dimethyl PGE2, 9-oxo-15R-hydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid
Application: EP receptor agonist
CAS 53658-98-3
MW: 364.5 D
From 86.00€ *
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Riluzole (hydrochloride)
Riluzole (hydrochloride)

Item number: Cay14577-10

Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 µM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value...
Keywords: PK 26124, 6-(trifluoromethoxy)-2-benzothiazolamine, monohydrochloride
CAS 850608-87-6
MW: 270.7 D
From 50.00€ *
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1-EBIO
1-EBIO

Item number: Cay14575-50

1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 µM in T84 human carcinoma cells). This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B. In this type of epithelium,...
Keywords: 1-Ethylbenzimidazolinone, 1-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Application: K+ channel activator
CAS 10045-45-1
MW: 162.2 D
From 43.00€ *
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4-DAMP
4-DAMP

Item number: Cay14574-50

4-DAMP is a potent antagonist of the muscarinic M3 receptor (pKi = 9.3). It is routinely used to study the regulation and functions of the M3 receptor. 4-DAMP also has a high affinity for the closely-related M5 receptor (pKi = 8.9).Formal Name: 4-[(2,2-diphenylacetyl)oxy]-1,1-dimethyl-piperidinium, monoiodide. CAS...
Keywords: 4-Diphenylacetoxy-N-methyl-piperidine methiodide, 4-[(2,2-diphenylacetyl)oxy]-1,1-dimethyl-piperidinium, monoiodide
Application: Muscarinic M3 receptor antagonist
CAS 1952-15-4
MW: 451.3 D
From 56.00€ *
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(R,S)-AMPA (hydrate)
(R,S)-AMPA (hydrate)

Item number: Cay14571-10

AMPA is the defining agonist for the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission. Because AMPA does not interfere with binding sites for kainic acid (Cay-78050) or NMDA (Cay-14581), it can be used to distinguish AMPA receptor-specific activity that contributes to a...
Keywords: alpha-amino-3-hydroxy-5-methyl-4-Isoxazolepropionic Acid, alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic...
Application: AMPA receptor agonist
MW: 186.2 D
From 134.00€ *
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Ro 25-6981 (maleate)
Ro 25-6981 (maleate)

Item number: Cay14578-50

Ro 25-6981 (maleate) is a potent, selective activity-dependent blocker of NMDA receptors containing the NR2B subunit (IC50s = 9 nM and 52 µM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A, respectively). Ro 25-6981 (maleate) displays neuroprotectant effects in vitro, protecting cortical neurons...
Keywords: alphaR-(4-hydroxyphenyl)-betaS-methyl-4-(phenylmethyl)-1-piperidinepropanol, 2Z-butenedioate
Application: NMDA receptor NR2B subunit antagonist
CAS 1312991-76-6
MW: 455.6 D
From 77.00€ *
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Purvalanol A
Purvalanol A

Item number: Cay14579-10

Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively. Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of...
Keywords: NG 60, (2R)-2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Application: CDK inhibitor
CAS 212844-53-6
MW: 388.9 D
From 43.00€ *
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