5 products were found matching "Cay14390"!

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8-iso-15-keto Prostaglandin E2
8-iso-15-keto Prostaglandin E2

Item number: Cay14390-100

8-iso-15-keto Prostaglandin E2 (8-iso-15-keto PGE2) is an isoprostane, one member of a large family of biomarkers produced by the free radical peroxidative degradation of membrane lipids. 8-iso-15-keto PGE2 is the theoretical first metabolite of 8-iso PGE2 via the 15-hydroxy PGDH pathway. While a number of potent...
Keywords: 8-epi-15-keto PGE2, 8-iso-15-keto PGE2, 9,15-dioxo-11alpha-hydroxy-(8beta)-prosta-5Z,13E-1-oic acid
Application: Bioactive lipid assays
CAS 914804-63-0
MW: 350.5 D
From 28.00€ *
Review
MK2 Inhibitor IV
MK2 Inhibitor IV

Item number: Cay14399-10

Activation of the p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2) pathway has been implicated in promoting pro-inflammatory cytokine production and related inflammatory diseases. MK2 inhibitor IV is a highly selective, non-ATP competitive MK2 inhibitor with an IC50 value of 0.11 µM....
Keywords: MK 25, 5-(4-chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-2-furancarboxamide, monohydrochloride
Application: MK2 inhibitor
CAS 1314118-94-9
MW: 509.4 D
From 109.00€ *
Review
G-36
G-36

Item number: Cay14397-10

G protein-coupled estrogen receptor (GPER), or GPR30, specifically binds natural and man-made estrogens. It is thought to be involved in estrogen-sensitive cancers. GPER knockout mice are fertile, although they exhibit thymic atrophy, impaired glucose tolerance, and altered bone growth. G-36 is a cell-permeable...
Keywords: (4S)-rel-4-(6-bromo-1,3-benzodioxol-5-yl)-3aR,4,5,9bS-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline
Application: GPER antagonist
CAS 1392487-51-2
MW: 412.3 D
From 43.00€ *
Review
Amifostine (hydrate)
Amifostine (hydrate)

Item number: Cay14398-50

Amifostine is a prodrug that through dephosphorylation by alkaline phosphatase is converted to an active thiol, WR 1065 that has free radical scavenging, DNA protective, and hypoxia inducing activities. Because of the differential expression of alkaline phosphatase in normal versus neoplastic tissues, the...
Keywords: Ethyol, WR 2721, 1-(dihydrogen phosphate)2-[(3-aminopropyl)amino]-ethanethiol, trihydrate
Application: Alkaline phosphatase substrate, radical scavenger prodrug
CAS 112901-68-5
MW: 268.3 D
From 84.00€ *
Review
MKT-077
MKT-077

Item number: Cay14395-10

MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s = 1.4-2.2 µM in vitro) through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. It has been shown to bind to an allosteric site conserved in Hsp70...
Keywords: FJ-776, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium,...
Application: Hsp70 inhibitor
CAS 147366-41-4
MW: 432 D
From 48.00€ *
Review