10 products were found matching "Cay14210"!

5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1. It is 18 times more potent than PGE2 in activating adenylate cyclase in NCB-20 cell homogenates. 5-trans PGE2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen...

Calmidazolium (chloride) is an inhibitor of calmodulin (CaM), inhibiting CaM-dependent phosphodiesterase and CaM-induced activation of erythrocyte calcium-transporting ATPase (IC50 = 0.15 and 0.35 µM, respectively). Calmidazolium also inhibits an array of calcium-transporting ATPases, including those from heart and...

Doxycycline is a broad-spectrum tetracycline antibiotic. It inhibits bacterial protein synthesis by binding to ribosomes. Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, when used at a concentration of 30 µM. It can be...

AKB48 is a pentyl indazole with structural similarity to JWH 018 adamantyl carboxamide (Cay-9001193) and STS-135 (Cay-11564), which are synthetic cannabinoids (CBs) with potential to be sold for recreational abuse. AKB48 N-(5-fluoropentyl) analog (Cay-12065) is a structural derivative of AKB48 in which a fluorine...

R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcepsilonRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 µM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce...

N-Propylamphetamine is an N-substituted amphetamine with a propyl group on the amphetamine backbone. It has about one-fourth the potency of N-ethylamphetamine (Cay-11557) in impairing the performance of rats in various tests. The toxicological properties of this compound are not known. This product is intended for...

Several aminoalkylindole cannabinoids (CBs), including JWH 018 (Cay-10900) and JWH 073 (Cay-10904), have been detected in herbal blends. JWH 146 (Cay-14232) is a (1-naphthoyl)pyrrole analog of JWH 018 that activates central CB1 and peripheral CB2 receptors with Ki values of 21 and 62 nM, respectively. This compound...

4-APB (hydrochloride) (Cay-14281) is an analytical reference standard categorized as a benzofuran. 4-APB is a potential metabolite of 4-MAPB (Cay-9002103) and 4-EAPB (Cay-9002102) based on the published metabolism of 5-MAPB (Cay-14109). At the time 4-APB (hydrochloride) (Cay-14281) was made available for purchase,...

5-Fluoropentyl-3-pyridinoylindole is a synthetic cannabinoid (CB) which shares the aminopentylindole structure of potent CBs like JWH 018 (Cay-10900). This compound has a novel pyridinoyl group replacing the more common naphthoyl group found in WIN 55,212-2 and related JWH compounds. It also contains an...

Extending the pluripotency of hematopoietic stem cells (HSC) is of key importance to the application of stem cell therapies in a variety of diseases. Loss of the expression of the cell surface proteins CD34 and CD133 is one marker of HSC differentiation and thus often monitored in assays to test potential compounds...