8 products were found matching "Cay14060"!

The prostaglandin E2 (PGE2) receptor EP1 is involved in triggering PGE2-mediated pain, neuronal survival and growth as well as the suppression of tumor metastasis. SC-19220 is a dibenzoxazepine that acts as a selective antagonist of PGE2 at the EP1 receptor. At doses between 0.3-300 µM, SC-19220 acts as a...

Dynasore is a cell-permeable, reversible inhibitor of dynamin 1, dynamin 2, and mitochondrial dynamin, Drp1 GTPase activity (IC50 = 15 µM). Through this action, dynasore inhibits clathrin-dependent vesicle formation and endocytosis, which is necessary for internalization of certain parasites and viruses, as well as...

A series of 2,5-phenethylamines, collectively referred to as 2Cs, have psychoactive effects, many are scheduled as illegal substances. 2C-G is described formally as 3,4-dimethyl-2,5-dimethoxyphenethylamine. It is analogous to the psychoactive, monomethylated compound 2C-D, which is a Schedule I Controlled Substance...

A series of 2,5-phenethylamines, collectively referred to as 2Cs, have psychoactive effects including potent activation of serotonin receptors and many are scheduled as illegal substances. 25G-NBOMe (hydrochloride) is a derivative of 2C-G, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine....

25I-NBF is an N-benzyl derivative of the phenethylamine hallucinogen 2C-I which acts as a highly potent partial agonist for the 5-HT2A receptor. 25I-NBF acts as a partial agonist of human 5-HT2A receptors demonstrating a Ki value of 0.26 nM and an EC50 value of 1.6 nM. A radiolabelled form of 25I-NBF has been used...

AM1248 (Cay-11282) is a synthetic cannabinoid (CB) with high affinities for both the central CB1 and the peripheral CB2 receptors (Kis = 11.9 and 4.8 nM, respectively). AM1248 azepane isomer is an analog of AM1248 characterized by an N-methyl azepane group attached to the indole in place of an N-methyl piperidine...

Propylthiouracil (PTU) is a thioamide antithyroid agent. It inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 µM, respectively). PTU (30 mg/kg) increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3'-triiodothyronine and...

Daltroban is a thromboxane receptor (TP) antagonist. It inhibits aggregation of isolated human platelets induced by the TP agonist U-46619 (Item no. 16450, IC50 = 77 nM). Daltroban increases mean pulmonary arterial pressure (MPAP), mean arterial pressure (MAP), and hematocrit levels in anesthetized rats (ED50s = 20,...