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GSK343
GSK343

Item number: Cay14094-25

The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. GSK343 is a cell-permeable EZH2 inhibitor (IC50 = 4 nM) that is 60-fold selective over EZH1 and >1,000-fold selective over other...
Keywords: N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1...
Application: Cell-permeable EZH2 inhibitor
CAS 1346704-33-3
MW: 541.7 D
From 50.00€ *
Review
AK-7
AK-7

Item number: Cay14004-25

The sirtuin SIRT2 is a deacetylase which targets alpha-tubulin, histone 4, forkhead transcription factors, and several other substrates. It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer's, Huntington's, and Parkinson's diseases. AK-7...
Keywords: N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide
Application: SIRT2 Inhibitor
CAS 420831-40-9
MW: 437.4 D
From 98.00€ *
Review