10 products were found matching "Cay13910"!

19(R)-hydroxy PGE1 is the major prostaglandin found in the semen of primates, including man. It is an agonist for the EP1 and EP3 receptor subtypes, and exhibits contractile activity on smooth muscle preparations. It has an EC50 of 320 nM for contracting guinea pig ileum, which express EP1 receptors, and an EC50 of...

Cafestol is a natural diterpene which is abundant in unfiltered coffee. It elevates serum cholesterol and triglycerides in humans, an effect which does not seem to occur in monkeys, hamsters, rats, or gerbils. Dietary cafestol does increase total cholesterol and triglycerides in ApoE3Leiden mice, an effect which is...

SQ 22,536 is an inhibitor of adenylyl cyclase with an IC50 value of 13 µM for inhibition of prostaglandin E1-stimulated increase in cAMP in intact platelets. It has been used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation of isolated pulmonary veins or aorta in several research...

3C-B-FLY is an alpha-methylated analog of 2C-B-FLY. This compound is also the dihydrofuran analog of 4-bromo-2,5-dimethoxyamphetamine (Cay-11142), which is a potent agonist of 5-HT2A and 5-HT2C. The physiological and toxicological properties of 3C-B-FLY are not known. This product is intended for forensic and...

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to beta-catenin activation of gene transcription. IWP-2 is an inhibitor of Wnt production...

3,4-Methylenedioxyamphetamine (MDA) is psychedelic and entactogenic drug that is scheduled as a controlled substance in the United States. 2,3-MDA is a structural isomer of MDA which differs only in the placement of the methyledioxy group. The physiological and toxicological properties of this compound are not...

MDL 72527 is a polyamine oxidase (PAO) inhibitor that inhibits spermine oxidase and N1-acetylpolyamine oxidase (IC50s = 6.1 and 0.02 µM, respectively). It does not inhibit monoamine oxidase or D-amino acid oxidase. MDL 72527 inhibits PAO-dependent H2O2 production in vitro and in vivo and is used to study the role of...

GW 803430 is an antagonist of melanin-concentrating hormone receptor 1 (MCH1, IC50 = 0.5 nM). It reduces cumulative body weight and food intake in diet-induced obese rats when administered at doses of 1 and 3 mg/kg. GW 803430 (10 and 30 mg/kg) decreases marble-burying behavior in mice, indicating anxiolytic...

EPZ005687 is a potent, selective inhibitor of the lysine methyltranferase EZH2 (Ki = 24 nM), the enzymatic subunit of polycomb repressive complex 2 (PRC2). It acts competitively with the EZH2 substrate S-adenosylmethionine. EPZ005687 has greater than 500-fold selectivity against 15 other protein methyltransferases...

Thiosildenafil is a derivative of the phosphodiesterase 5 (PDE5) inhibitor sildenafil (Cay-10008671).Formal Name: 5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidine-7-thione. CAS Number: 479073-79-5. Molecular Formula: C22H30N6O3S2. Formula Weight:...