The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). It weakly...

Misoprostol is an analog of prostaglandin E1 (PGE1, Cay-13010) and an agonist of the PGE2 receptor subtypes EP2 and EP3. It binds to EP1, EP2, EP3-III, and EP4 receptors (Kis = 35.675, 10.249, 0.319, 5.499 µM, respectively) and is selective for EP receptors over DP, FP, IP, and TP receptors (Kis = >100 µM for all)....

Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid (Cay-90310). It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreated tissues from humans, mice, and sardines. RvD4, at 10 ng/mouse, reduces neutrophil...

Farnesyl alcohol is an isoprenoid that has been found in aromatic plants and has diverse biological activities. It is an agonist of peroxisome proliferator-activator receptor alpha (PPARalpha) and PPARgamma (EC50s = 5.5 and 28 µM, respectively, in a reporter assay using CV-1 cells) and increases the expression of...