7 products were found matching "Cay13821-%25"!

TAK-242 is an antagonist of toll-like receptor 4 (TLR4) with an IC50 value of 0.68 µM in a secreted alkaline phosphatase (SEAP) assay. It selectively binds to TLR4 over TLR1-3 and TLR5-10 when used at a concentration of 100 nM. TAK-242 (1 µM) prevents the interaction of TLR4 with its adaptor proteins TIRAP or TRAM...

Fmoc-Succinimide (Fmoc-OSu) is a mixed carbamate reagent for the selective preparation of N-(9-fluorenylmethoxycarbonyl) derivatives of hydroxyamino acids and hydroxyamino acid esters in high yields. Fmoc-OSu is a more preferable alternative to the use of the chloroformate, Fmoc-Cl, because it eliminates the...

(S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin (Cay-13013), which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5...

JWH 030 (Cay-10831) is a naphthoyl pyrrole cannabimimetic which activates the CB1 receptor (EC50 = 30.5 nM for rat, Ki = 87 nM for mouse) better than CB2 (EC50 = 552 nM for human CB2). JWH 030 is quite potent in vivo in the mouse spontaneous activity and tail flick (antinociception) assays (ED50 = 26.8 µM/kg). It...

Casein kinase 2 (CK2) is a kinase with many targets and diverse roles in cell signaling and disease. TBCA is a selective, cell-permeable inhibitor of CK2 (IC50 = 0.11 µM, Ki = 77 nM) that has minimal effect on a panel of 28 other kinases. It induces cell death in Jurkat adult T cell leukemia cells (DC50 = 7.7 µM),...

ML-291 is a novel activator of the apoptotic arm of the unfolded protein response (UPR), but not the adaptive arm. Specifically, it activates signaling through PERK/eIF2alpha/CHOP (EC50 = 762 nM) but not through IRE1/XBP1 (IC50 > 80 µM). ML-291 induces apoptosis in mouse embryonic fibroblasts overexpressing CHOP...

Colchicoside is a glycoside form of 3-demethylcolchicine that has been found in G. superba. Unlike cholchicine and 3-demethylcolchicine, colchicoside does not displace [3H]-colchicine from rat brain tubulin in vitro when used at a concentration of 25 µM. Colchicoside (1 and 10 µM) increases levels of the cytochrome...