Endocannabinoids such as 2-arachidonoyl glycerol (2-AG, Cay-62160) and arachidonoyl ethanolamide (AEA, Cay-90050) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the...

Hinokitiol is a tropolone originally isolated from the heart wood of T. plicata that has diverse biological activities, including antifungal, antibacterial, and antiproliferative properties. It inhibits proliferation of HCT-116 and SW-620 colon cancer cells (IC50s = 4.5 and 4.4 µM, respectively), arrests the cell...

Nonsense mutations create a premature termination of mRNA translation and have been implicated in various genetic disorders, including muscular dystrophy and cystic fibrosis. PTC-124 is a nonaminoglycoside that has been reported to selectively induce ribosomes to read through premature nonsense stop signals on mRNA,...

Jaceosidin is a natural methylated trihydroxyflavone first isolated from plants of the Compositae family. Like many flavones, jaceosidin has antioxidative actions on cells in culture. It induces cell cycle arrest and apoptosis in cancer cells, suggesting potential roles in cancer therapy. Jaceosidin also blocks cell...