CCMI is a positive allosteric modulator (PAM) of alpha7 nicotinic acetylcholine receptors (nAChRs). It enhances ACh-, nicotine-, or choline-induced currents in Xenopus oocytes expressing recombinant human alpha7 nAChRs (EC50s = 0.7, 0.6, and 0.5 µM, respectively). In vivo, CCMI (0.3 and 1 mg/kg, i.v.) improves...

Salicin is an alcoholic beta-glucoside derived from willow bark that produces anti-inflammatory (including analgesic and antipyretic) effects very similar to that of aspirin (Cay-70260). It acts as a non-selective COX inhibitor, exhibiting IC50 values > 100 µM for COX-1 and COX-2.Formal Name:...

7-methoxy Apigeninidin is a 3-deoxyanthocyanin fungicide originally isolated from Sorghum and a derivative of apigeninidin (Cay-19756). It is active against the radial growth of G. sorghi and spore germination of P. oryzae (IC50 = 50 ppm for both).Formal Name: 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-1-benzopyrylium,...

Tetrahydrocurcumin is a metabolite of curcumin (Cay-81025, Cay-81025.1) that has diverse biological activities, including antioxidant, anti-inflammatory, anti-angiogenic, and anticancer properties. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals in a cell-free assay with an EC50 value of 16.8...