8 products were found matching "Cay13733-%25"!

ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor-alpha and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.Formal Name: 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(5-phenylthio)methyl]phenyl]-2-propenamide. CAS...

2',3',5'-triacetyl-5-Azacytidine is a prodrug form of the DNA methyltransferase inhibitor 5-azacytidine (Cay-11164). It decreases promoter methylation of P15 in L1210 mouse leukemia cells when used at concentrations of 1 and 100 µM. 2',3',5'-triacetyl-5-Azacytidine (10 µM) reduces HIV-1 infection in, and increases...

PI-1840 is an inhibitor of chymotrypsin-like (CTL) proteasome activity (IC50 = 27 nM). It is selective for the CTL activity over the trypsin-like (TL) and peptidylglutamyl peptide hydrolyzing (PGPH) activities (IC50s = >100 µM for both), as well as for the 20S constitutive proteasome over the immunoproteasome (IC50s...

Temoporfin is a synthetic chlorin with light-activated actions. When administered systemically, temoporfin accumulates in tumor cells. When stimulated with light (650-652 nm) in the presence of oxygen, reactive oxygen species are generated, leading to necrosis within the tumor. Different approaches to using...

Valproic acid is an analog of the natural fatty acid valeric acid that inhibits class I histone deacetylases (HDACs) with an IC50 value of approximately 2 mM. It decreases the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia, an effect that is reversed by...

E-64d is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases and has diverse biological activities. It is a synthetic analog of E-64 (Cay-10007963) and prodrug form of E-64c (Cay-10007964) that inhibits calpain and the cysteine proteases cathepsins F, -K, -B, -H, and...

1,2-Didocosahexaenoyl-sn-glycero-3-PC is a phospholipid that contains docosahexaenoic acid (Cay-90310, Cay-17950) at the sn-1 and sn-2 positions. It has been used in the formation of polyunsaturated endoplasmic reticulum-targeting liposomes (PERLs) that reduce cellular cholesterol levels in human peripheral blood...

Eldecalcitol is a derivative of the vitamin D3 receptor agonist and vitamin D3 active metabolite calcitriol (Cay-71820). It induces calcium release in an in vitro bone mobilization assay using isolated mouse calvaria when used at a concentration of 10 nM. Eldecalcitol (50 nM) reduces LPS-induced pyroptosis and...