- Search results for Cay13732-%25
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11 products were found matching "Cay13732-%25"!
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Item number: Cay13337-25
ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor-alpha and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.Formal Name: 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(5-phenylthio)methyl]phenyl]-2-propenamide. CAS...
Keywords: | 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(5-phenylthio)methyl]phenyl]-2-propenamide |
Application: | Tyrosine kinase inhibitor |
CAS | 107761-24-0 |
MW: | 354.4 D |
From 52.00€
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Item number: Cay21373-25
4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA (Cay-90310) with antiproliferative and PPARgamma agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 µM, however it increased proliferation of MCF-7...
Keywords: | 4-oxo DHA, 4-oxo-5E,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid |
Application: | Putative DHA metabolite, PPARgamma agonist |
CAS | 845673-74-7 |
MW: | 342.5 D |
From 66.00€
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Item number: Cay13327-25
PPM-18 is a naphthoquinone compound that inhibits NF-kappaB activation in vitro and in vivo (IC50 = 5 µM). Through this action, it inhibits the expression of inducible nitric oxide synthase (iNOS) in macrophages treated with lipopolysaccharide and suppresses inflammation and sepsis.Formal Name:...
Keywords: | NSC 73233, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-benzamide |
Application: | NF-kappaB inhibitor |
CAS | 65240-86-0 |
MW: | 277.3 D |
From 26.00€
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Item number: E-AB-13732.20
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation...
Keywords: | Anti-EFP, Anti-TRIM25, Anti-RING finger protein 147, Anti-Zinc finger protein 147, Anti-E3 ubiquitin/ISG15 ligase TRIM25,... |
Application: | IHC, ELISA |
Host: | Rabbit |
Species reactivity: | human |
From 71.00€
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Item number: Cay17323-25
7-fluoro Tryptamine is a tryptamine derivative that potentially agonizes 5-HT serotonin receptors. Although the biological effects of this compound have not been reported, certain hallucinogenic typtamines containing a fluorine substitution at the 5-, 6-, or 7-position have been shown to have 5-HT2C receptor...
Keywords: | 7-fluoro-1H-indole-3-ethanamine, monohydrochloride |
Application: | Analytical reference standard, Tryptamine derivative, Potential 5-HT2C agonist |
CAS | 159730-09-3 |
MW: | 214.7 D |
From 43.00€
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Item number: Cay16373-25
4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution....
Keywords: | 4-SU, NSC 518132, 4-thio-uridine |
Application: | RNA-RNA crosslinking |
CAS | 13957-31-8 |
MW: | 260.3 D |
From 50.00€
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Item number: Cay17373-25
ML-240 is an ATP-competitive inhibitor of the D2 domain of the ATPase p97 (IC50 = 0.11 µM, Ki = 0.22 µM). It disrupts the endoplasmic reticulum-associated degradation (ERAD) and autophagy pathways, preventing the degradation of p97-dependent proteasome substrates (IC50 = 0.9 µM) and causing accumulation of ubiquitin...
Keywords: | 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine |
Application: | p97 ATPase inhibitor |
CAS | 1346527-98-7 |
MW: | 396.4 D |
From 66.00€
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Item number: Cay23731-25
Naloxegol is a peripherally acting antagonist of the µ-opioid receptor (Ki = 7.42 nM, pA2 = 7.95). It is selective for the µ-opioid receptor over the delta-opioid receptor (Ki = 866 nM). Naloxegol also acts as a partial agonist of kappa-opioid receptors in vitro (EC50 = 47 nM for [35S]GTPgammaS binding) but lacks...
Keywords: | AZ 13337019, NKTR-118,... |
Application: | Opioid receptor antagonist |
CAS | 1354744-91-4 |
MW: | 741.8 D |
From 238.00€
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Item number: Cay31372-25
Tioxolone is an inhibitor of carbonic anhydrase I (CAI, Ki = 91 nM). It is selective for CAI over CAII, -III, -IV, -VA, -VB, -VI, -VII, -IX, -XII, and -XIV (Kis = 4,930-9,040 nM). Tioxolone is active against Gram-positive or -negative bacteria, including M. tuberculosis. It is also active against dermatophytes,...
Keywords: | Thioxolone, 6-hydroxy-1,3-benzoxathiol-2-one |
Application: | Carbonic anhydrase I inhibitor, Keratolytic |
CAS | 4991-65-5 |
MW: | 168.2 D |
From 65.00€
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Item number: Cay13032-25
The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50...
Keywords: | N-[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea |
Application: | FGFR inhibitor |
CAS | 219580-11-7 |
MW: | 523.7 D |
From 53.00€
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Item number: Cay11732-25
O6-Methylguanine-DNA methyltransferase (MGMT) (Cay-11176) is a DNA repair protein which removes an alkyl group from the O6 position on guanine in an autoinactivating reaction. Although important in normal DNA repair, this reaction confers resistance to treatments that use O6-alkylating agents to produce...
Keywords: | PaTrin 2, 6-[(4-bromo-2-thienyl)methoxy]-9H-purin-2-amine |
Application: | MGMT inhibitor |
CAS | 192441-08-0 |
MW: | 326.2 D |
From 52.00€
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