10 products were found matching "Cay13732"!

FUB-JWH 018 (Cay-17332) is an analytical reference standard that is structurally classified as a synthetic cannabinoid. The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.Formal Name:...

PPM-18 is a naphthoquinone compound that inhibits NF-kappaB activation in vitro and in vivo (IC50 = 5 µM). Through this action, it inhibits the expression of inducible nitric oxide synthase (iNOS) in macrophages treated with lipopolysaccharide and suppresses inflammation and sepsis.Formal Name:...

Synonyms: Cytochrome P450 1A (fish). Immunogen: rainbow trout CYP1A amino acids 277-294. Formulation: (Request formulation change), Purified IgG in 0.1 M sodium phosphate, pH 7.4, containing 0.15 M sodium chloride, 12.3 mM sodium azide, and 1% BSA. Host: Mouse. Isotype: IgG3-kappa. Applications: ELISA and WB....

Hyperphosphorylation of the tau protein leads to its aggregation and formation of neurofibrillary tangles, a hallmark of Alzheimer's disease and other tauopathic, neurodegenerative disorders. Tau is also dynamically modified by the addition and cleavage of O-linked beta-N-acetylglucosamine (O-GlcNAc) moieties, which...

ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor-alpha and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.Formal Name: 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(5-phenylthio)methyl]phenyl]-2-propenamide. CAS...

Diverse signal transduction pathways impinging on the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly(ADP-ribosylation), ubiquitination, and methylation. These modifications play critical roles in regulating chromatin structure and gene...

Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB...

15(S)-15-methyl Prostaglandin E1 (15(S)-15-methyl PGE1) is a metabolically stable synthetic analog of PGE1 (Cay-13010). In sharp contrast to the bronchodilatory effects of PGE1, 15(S)-15-methyl PGE1 is a weak constrictor of human respiratory tract smooth muscle.Formal Name:...

Ixabepilone is an epothilone with broad-spectrum anticancer activity against a panel of 21 cancer cell lines (IC50s = 1.4-34.5 nM). It stabilizes and induces the polymerization of microtubules and induces cell cycle arrest during mitosis. Ixabepilone is cytotoxic to HCT116/VM46 and A2780Tax clonogenic cells, which...

Tioxolone is an inhibitor of carbonic anhydrase I (CAI, Ki = 91 nM). It is selective for CAI over CAII, -III, -IV, -VA, -VB, -VI, -VII, -IX, -XII, and -XIV (Kis = 4,930-9,040 nM). Tioxolone is active against Gram-positive or -negative bacteria, including M. tuberculosis. It is also active against dermatophytes,...