- Search results for Cay13719
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21 products were found matching "Cay13719"!
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Item number: Cay13791-1
Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect...
Keywords: | Telomeric Repeat Binding Factor 2, TERF2, TRBF2, TTAGGG Repeat Binding Factor 2 |
Application: | ChIP, ICC, IF, IHC, IP, WB |
Host: | Goat |
Species reactivity: | human |
417.00€
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Item number: Cay19739-10
GSK583 is a selective inhibitor of RIP-like interacting CLARP kinase (RICK also known as RIP2 kinase, IC50 = 5 nM). RIP2 Kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of...
Keywords: | 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine |
Application: | Selective RIPK2 inhibitor |
CAS | 1346547-00-9 |
MW: | 398.5 D |
From 60.00€
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Item number: Cay10739-10
Isoliquiritigenin is a flavonoid that is found in Glycyrrhizae species and has diverse biological activities including anticancer, anti-steatotic, antioxidant, anti-inflammatory, gastroprotective, and estrogenic properties. It reduces tumor growth in an NCI-H1975 non-small cell lung cancer (NSCLC) mouse xenograft...
Keywords: | GU 17, ILQ, ISL, 1-(2E,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one |
Application: | Bioactive flavonoid |
CAS | 961-29-5 |
MW: | 256.3 D |
From 35.00€
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Item number: Cay17739-10
UNBS5162 is a naphthalimide that antagonizes the expression of CXCL chemokines. In vitro exposure of PC-3 prostate cancer cells to 1 µM UNBS5162 for five successive days was shown to decrease the expression of proangiogenic CXCL chemokines. UNBS5162 also demonstrates antiangiogenic properties in vivo in an...
Keywords: | N-[2-[2-(dimethylamino)ethyl]-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-5-yl]-urea |
Application: | DNA intercalation |
CAS | 956590-23-1 |
MW: | 326.4 D |
From 109.00€
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Item number: Cay13789-1
TIP60, originally isolated as an HIV-1 TAT-interactive protein, is known to interact with the viral TAT protein that leads to HTATIP polyubiquitination and targets it for degradation. It belongs to the MYST family of histone acetyltransferases (HATs). TIP60 is a catalytic subunit of the NuA4 HAT complex which is...
Keywords: | KAT5, Lysine Acetyltransferase 5 |
Application: | IHC, WB |
Host: | Rabbit |
Species reactivity: | human, broad |
451.00€
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Item number: Cay13197-25
gamma-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Abeta), a 39- to 42-amino acid peptide which forms the amyloid plaques...
Keywords: | GSI-IX, N-[2S-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-glycine, 1,1-dimethylethyl ester |
Application: | gamma-secretase inhibitor |
CAS | 208255-80-5 |
MW: | 432.5 D |
From 75.00€
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Item number: Cay13179-1
Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, yielding a free fatty acid and a lysophospholipid as products. There are three broad classes of PLA2, secretory (sPLA2), calcium-dependent cytosolic (cPLA2), and calcium-independent cytosolic (iPLA2), that...
Keywords: | 1,1,1,2,2-pentafluoro-7-phenyl-3-heptanone |
Application: | iPLA2 inhibitor |
CAS | 1071000-98-0 |
MW: | 280.2 D |
From 49.00€
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Item number: Cay17319-1
Mirabegron is an agonist of the beta3-adrenergic receptor (beta3-AR). It induces cAMP accumulation in CHO cells expressing the beta3-AR but not the beta1- or beta2-AR (EC50s = 0.0224, >10, and >10 µM, respectively). Mirabegron reduces contraction induced by carbamoylcholine (Cay-14486) of isolated rat and human...
Keywords: | YM-178, 2-amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide |
Application: | beta3-adrenergic receptor agonist |
CAS | 223673-61-8 |
MW: | 396.5 D |
From 50.00€
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Item number: Cay11937-50
Olanzapine is an atypical antipsychotic that binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, and 5-HT3 (Kis = 4, 11, and 57 nM, respectively). It also binds to M1 muscarinic acetylcholine, alpha1-adrenergic, and...
Keywords: | LY170053, 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine |
Application: | Forensic studies |
CAS | 132539-06-1 |
MW: | 312.4 D |
From 43.00€
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Item number: Cay15379-1
Complex I, also known as NADH:ubiquinone oxidoreductase or NADH dehydrogenase (ubiquinone), catalyzes the transfer of electrons from NADH to ubiquinone (also known as coenzyme Q10) as part of the respiratory chain leading to ATP generation. Piericidin A is an irreversible inhibitor of mitochondrial complex I that...
Keywords: | AR 054, Shaoguanmycin B, SN 198E,... |
Application: | Mitochondrial Complex I inhibitor |
CAS | 2738-64-9 |
MW: | 415.6 D |
From 171.00€
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Item number: Cay13279-1
Fatty acid amide hydrolase (FAAH) degrades N-acyl ethanolamines (NAEs), including the endocannabinoid arachidonoyl ethanolamide (AEA). PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 µM). It covalently binds FAAH on Ser241 at the catalytic site, resulting in prolonged elevation of AEA...
Keywords: | N-3-pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide |
Application: | FAAH inhibitor |
CAS | 1196109-52-0 |
MW: | 456.5 D |
From 39.00€
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Item number: Cay17379-1
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin (Cay-13346)) and regulate different pathways. OSI-027 is an inhibitor of the catalytic site of...
Keywords: | trans-4-[4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]-cyclohexanecarboxylic acid |
Application: | mTORC1 / mTORC2 inhibitor |
CAS | 936890-98-1 |
MW: | 406.4 D |
From 50.00€
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