- Search results for Cay13717-%25
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4 products were found matching "Cay13717-%25"!
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Item number: Cay17371-25
Toyocamycin is a natural adenosine analog first isolated from Streptomyces and shown in early studies to be cytotoxic to bacteria, fungi, and cancer cells and to have antiviral activities. Toyocamycin prevents IRE1alpha-induced mRNA cleavage (IC50 = 80 nM) and inhibits constitutive activation of XBP1 in multiple...
Keywords: | NSC 63701, NSC 99843, 4-amino-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, hydrate |
Application: | Natural adenosine analog, IRE1alpha-induced mRNA cleavage inhibitor |
MW: | 291.3 D |
From 43.00€
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Item number: Cay13217-25
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the terminal enzyme in the biosynthesis of PGE2. MF63 is a potent, selective, and orally active inhibitor of human mPGES-1 (IC50 = 1.3 nM). It displays greater than 1,000-fold selectivity over other prostanoid synthases. MF63 also potently inhibits guinea pig...
Keywords: | 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile |
Application: | mPGES-1 inhibitor |
CAS | 892549-43-8 |
MW: | 378.8 D |
From 46.00€
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Item number: Cay16717-25
Carbonic anhydrases are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to form bicarbonate ion plus a proton. Carbonic anhydrases IX (CAIX) and CAXII are hypoxia and HIF-1-inducible proteins located in cellular transmembranes that regulate intra- and extracellular pH under hypoxic...
Keywords: | NSC 213841, 4-[[[(4-fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide |
Application: | CAIX / CAXII inhibitor |
CAS | 178606-66-1 |
MW: | 309.3 D |
From 65.00€
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Item number: Cay19717-25
PHGDH-inactive is an inactive analog of the 3-phosphoglycerate dehydrogenase (PHGDH) inhibitors NCT-502 (Cay-19716) and NCT-503 (Cay-19718). Unlike the inhibitors, PHGDH-inactive does not inhibit PHGDH in vitro (IC50s = >57, 3.7, and 2.5 µM for PHGDH-inactive, NCT-502, and NCT-503, respectively), block serine...
Keywords: | 3-Phosphoglycerate Dehydrogenase-inactive, N-(4,6-dimethyl-2-pyridinyl)-4-(4-pyridinyl)-1-piperazinecarbothioamide |
Application: | PHGDH inhibitor control |
CAS | 1914971-16-6 |
MW: | 327.5 D |
From 66.00€
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