8 products were found matching "Cay13708-%25"!

Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 µM). It induces growth suppression and cell death of certain types of cancer cells in culture.Formal Name: N1-hydroxy-N8-3-pyridinyl-octanediamide. CAS Number: 382180-17-8. Molecular Formula: C13H19N3O3. Formula Weight:...

Transferrin receptor (TfR1), also known as CD71, is a homodimeric transmembrane receptor for transferrin (Cay-32030) that facilitates iron delivery into cells and is encoded by TFRC in humans. It is composed of two TfR1 monomers, each containing a cytoplasmic tail, an internalization motif, a membrane-spanning...

(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Cay-13258). It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively). It also stimulates LC3 lipidation and the...

VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38alpha and p38beta (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1beta, and TNF-alpha production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml,...

3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC. BX-912 is a potent, ATP-competitive inhibitor of PDK1 (IC50 = 26 nM). It less effectively inhibits a panel of...

DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230...

SR 3677 is a potent, ATP-competitive inhibitor of Rho-associated kinases (ROCKs) that shows greater potency against ROCK2 than ROCK1 in enzyme and cell-based assays (IC50 values are 3 and 56 nM, respectively). At 3 µM, SR 3677 inhibits only 5 (Akt3, Clk1, Clk2, Clk4, Lats2) out of 353 kinases with greater than 50%...

DL-3,4-Dihydroxyphenyl glycol is an active metabolite of the endogenous neurotransmitter norepinephrine (Cay-35580). It is produced by the deamination of norepinephrine by monoamine oxidase (MAO) in the cytosol. DL-3,4-Dihydroxyphenyl glycol scavenges DPPH (Cay-14805) radicals in a cell-free assay (IC50 = 1.55 µM)....