- Search results for Cay13707-%25
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8 products were found matching "Cay13707-%25"!
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Item number: Cay17370-25
STF-083010 is an inhibitor of the IRE1/XBP1 pathway, blocking IRE1 endonuclease activity without affecting its kinase activity after endoplasmic reticulum (ER) stress both in vitro and in vivo. STF-083010 (60 µM) reduces the splicing of XBP1 by IRE1 in the presence of thapsigargin (Cay-10522), an ER stress inducer....
Keywords: | IRE1 Inhibitor I, N-[(2-hydroxy-naphthalenyl)methylene]-2-thiophenesulfonamide |
Application: | ERN1 endonuclease inhibitor |
CAS | 307543-71-1 |
MW: | 317.4 D |
From 60.00€
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Item number: Cay13107-50
Pimecrolimus is a natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase). Presumably through these actions, it blocks the activation of T cells by allogeneic dendritic cells (IC50 = 0.55 nM) without affecting dendritic cells. Moreover,...
Keywords: | Elidel, SDZ-ASM 981,... |
Application: | Calcineurin inhibitor |
CAS | 137071-32-0 |
MW: | 810.5 D |
From 35.00€
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Item number: Cay10007737-25
Lipoxin A4-d5 (LXA4-d5) contains five deuterium atoms at the 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of LXA4 by GC- or LC-mass spectrometry (MS). LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or...
Keywords: | 5(S),6(R),15(S)-TriHETE-d5, 5(S),6(R)-LXA4-d5, 5S,6R,15S-trihydroxyicosa-7E,9E,11Z,13E-tetraenoic-19,19,20,20,20-d5 acid |
Application: | Standard |
CAS | 1622429-53-1 |
MW: | 357.5 D |
From 257.00€
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Item number: Cay13307-25
D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC, Ki = 6.4 µM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations...
Keywords: | Tricyclodecan-9-yl xanthogenate, O-(octahydro-4,7-methano-1H-inden-5-yl) ester, carbonodithioic acid, monopotassium salt |
Application: | PC-PLC inhibitor |
CAS | 83373-60-8 |
MW: | 266.5 D |
From 50.00€
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Item number: Cay16707-25
Baricitinib is an inhibitor of JAK1 and JAK2 (IC50s = 0.0059 and 0.0057 µM, respectively). It is selective for JAK1 and JAK2 over JAK3, TYK2, c-Met, and checkpoint kinase 2 (Chk2, IC50s = >0.4, 0.053, >10, and >1 µM, respectively). Baricitinib inhibits IL-6-induced phosphorylation of STAT3 in isolated human...
Keywords: | INCB 028050, LY3009104, 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile |
Application: | JAK1 / JAK2 inhibitor |
CAS | 1187594-09-7 |
MW: | 371.4 D |
From 50.00€
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Item number: Cay14707-25
Cyclin-dependent kinases (CDKs) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. Dinaciclib inhibits CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC50 values of 3, 1, 1, and 4 nM, respectively. Compared to the...
Keywords: | SCH 727965, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2S-piperidineethanol |
Application: | CDK1 / CDK2 / CDK5 / CDK9 inhibitor |
CAS | 779353-01-4 |
MW: | 396.5 D |
From 125.00€
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Item number: Cay13207-25
Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1 and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are...
Keywords: | N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalenecarboxamide |
Application: | PLD2 inhibitor |
CAS | 1130067-34-3 |
MW: | 428.5 D |
From 68.00€
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Item number: Cay11707-25
6-Gingerol is a natural chemical found in the rhizomes of ginger (Z. officinale). It shares the vanillyl group found on capsaicin (Cay-92350) and, like capsaicin, activates the transient receptor potential vanilloid receptor TRPV1 (EC50 = 3.3 µM) as well as the TRP ankyrin receptor TRPA1 (EC50 = 10.4 µM). 6-Gingerol...
Keywords: | 5S-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone |
Application: | TRPV1 & TRPA1 activator |
CAS | 23513-14-6 |
MW: | 294.4 D |
From 66.00€
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