- Search results for Cay13704-%25
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9 products were found matching "Cay13704-%25"!
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Item number: Cay17034-25
PF-543 is a potent inhibitor of sphingosine kinase 1 (SPHK1, IC50 = 2 nM) that inhibits sphingosine-1-phosphate (S1P) binding to human recombinant SPHK1 (Ki = 3.6 nM). It is selective for SPHK1 over SPHK2 (IC50 = 356 nM) as well as a panel of protein and lipid kinases and S1P receptors at a concentration of 10 µM....
Keywords: | 1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2R-pyrrolidinemethanol, monohydrochloride |
Application: | Sphingosine kinase 1 inhibitor |
CAS | 1706522-79-3 |
MW: | 502.1 D |
From 43.00€
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Item number: Cay10007833-25
CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1, IC50 = 0.6 nM). It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral...
Keywords: | 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-3-azetidinecarboxylic acid |
Application: | S1P1 receptor agonist |
CAS | 635701-59-6 |
MW: | 391.5 D |
From 43.00€
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Item number: Cay14703-25
The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor, have been implicated in the development and progression of several human cancers. PHA-665752 is an ATP-competitive, active-site inhibitor of the catalytic activity of c-Met kinase (Ki = 4 nM, IC50 = 9 nM). It exhibits >50-fold selectivity...
Keywords: | (3Z)-5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-... |
Application: | ATP-competitive, active-site c-Met kinase inhibitor |
CAS | 477575-56-7 |
MW: | 641.6 D |
From 66.00€
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Item number: Cay31704-25
Guanosine 5'-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5'-triphosphate (GTP, Cay-16060). It has been used to study the conformations of GTPases. GDP (100 µM) activates sulfonylurea receptor 2B (SUR2B) linked to the inward-rectifier potassium channel 6.1 (Kir6.1) in HEK293T...
Keywords: | GDP, guanosine, 5'-(trihydrogen diphosphate), disodium salt, hydrate |
Application: | Purine nucleotide |
MW: | 487.2 D |
From 39.00€
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Item number: Cay17704-25
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Dickkopf-1 (Dkk1) antagonizes Wnt signaling and has important roles in bone formation, cancer, and Alzheimer's disease. WAY-262611 is an inhibitor of Dkk1 that activates the Wnt...
Keywords: | BML-WN110, Dickkopf-1 Inhibitor, Dkk1 Inhibitor, 1-[4-(2-naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine |
Application: | DKK1 Inhibitor |
CAS | 1123231-07-1 |
MW: | 318.4 D |
From 35.00€
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Item number: Cay13304-25
Biotin-XX hydrazide is a biotylating reagent for carbohydrates and carbonyl compounds that contains two aminohexanoic spacers to increase the efficiency of avidin-binding by alleviating steric hindrance.Formal Name:...
Keywords: | 6-[[6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxohexyl]amino]-hexanoic acid... |
Application: | Biotinylation |
CAS | 211237-33-1 |
MW: | 484.7 D |
From 88.00€
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Item number: Cay13604-25
WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of phosphatidylinositol 3-kinase alpha (IC50 = 1,026 nM) and other kinases. WYE-354 induces G1 cell cycle arrest in both rapamycin-sensitive and...
Keywords: | 4-[6-[4-[(methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid,... |
Application: | mTOR inhibitor |
CAS | 1062169-56-5 |
MW: | 495.5 D |
From 125.00€
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Item number: Cay19704-25
MRS2578 is an antagonist of the purinergic P2Y6 receptor (IC50s = 37 and 98 nM for human and rat receptors, respectively). It is without effect at other purinergic receptors. MRS2578 is used to study the cellular and physiological roles of P2Y6.Formal Name:...
Keywords: | N,N''-1,4-butanediylbis[N'-(3-isothiocyanatophenyl)-thiourea |
Application: | P2Y6 receptor antagonist |
CAS | 711019-86-2 |
MW: | 472.7 D |
From 60.00€
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Item number: Cay13804-25
gamma-Glutamyl transferase (GGT) is involved in the transfer of amino acids across the plasma membrane as well as in glutathione metabolism. Serum GGT activity is commonly used as a marker of liver dysfunction and alcohol abuse. It is also useful as a biomarker of type 2 diabetes and cardiovascular disease. OU749 is...
Keywords: | N-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-benzenesulfonamide |
Application: | gamma-Glutamyl transferase inhibitor |
CAS | 519170-13-9 |
MW: | 361.4 D |
From 31.00€
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