- Search results for Cay13702-%25
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7 products were found matching "Cay13702-%25"!
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Item number: Cay13207-25
Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1 and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are...
Keywords: | N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalenecarboxamide |
Application: | PLD2 inhibitor |
CAS | 1130067-34-3 |
MW: | 428.5 D |
From 68.00€
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Item number: Cay13307-25
D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC, Ki = 6.4 µM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations...
Keywords: | Tricyclodecan-9-yl xanthogenate, O-(octahydro-4,7-methano-1H-inden-5-yl) ester, carbonodithioic acid, monopotassium salt |
Application: | PC-PLC inhibitor |
CAS | 83373-60-8 |
MW: | 266.5 D |
From 50.00€
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Item number: Cay17730-25
Liproxstatin-1 is a ferroptosis inhibitor. It inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in mouse embryonic fibroblasts (MEFs) with an inducible knockdown of glutathione peroxidase 4 (Gpx4-/- MEFs) when used at a concentration of 50 nM. Liproxstatin-1 also inhibits ferroptosis induced by...
Keywords: | N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine |
Application: | Ferroptosis inhibitor |
CAS | 950455-15-9 |
MW: | 340.9 D |
From 75.00€
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Item number: Cay17370-25
STF-083010 is an inhibitor of the IRE1/XBP1 pathway, blocking IRE1 endonuclease activity without affecting its kinase activity after endoplasmic reticulum (ER) stress both in vitro and in vivo. STF-083010 (60 µM) reduces the splicing of XBP1 by IRE1 in the presence of thapsigargin (Cay-10522), an ER stress inducer....
Keywords: | IRE1 Inhibitor I, N-[(2-hydroxy-naphthalenyl)methylene]-2-thiophenesulfonamide |
Application: | ERN1 endonuclease inhibitor |
CAS | 307543-71-1 |
MW: | 317.4 D |
From 60.00€
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Item number: Cay13870-25
Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 µM). It induces growth suppression and cell death of certain types of cancer cells in culture.Formal Name: N1-hydroxy-N8-3-pyridinyl-octanediamide. CAS Number: 382180-17-8. Molecular Formula: C13H19N3O3. Formula Weight:...
Keywords: | N1-hydroxy-N8-3-pyridinyl-octanediamide |
Application: | Histone deacetylases Inhibitor |
CAS | 382180-17-8 |
MW: | 265.3 D |
From 82.00€
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Item number: Cay31370-25
Mesoridazine is an active metabolite of the typical antipsychotic thioridazine (Cay-14400). It is formed via sulfoxidation of thioridazine by the cytochrome P450 (CYP) isoform CYP2D6 in human liver microsomes. It binds to histamine H1, dopamine D2, muscarinic acetylcholine, and alpha1- and alpha2-adrenergic...
Keywords: | NSC 186066, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfinyl)-10H-phenothiazine |
Application: | Antipsychotic, active thioridazine metabolite |
CAS | 5588-33-0 |
MW: | 386.6 D |
From 50.00€
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Item number: Cay23701-25
NSC 319726 is a reactivator of p53R175, a p53 conformational mutant that cannot bind DNA. It selectively inhibits growth of human tumor cell lines containing mutant p53 over those containing wild-type p53 (IC50s = 0.1-1 and >10 µM, respectively). NSC 319726 induces apoptosis in TOV112D (p53R175H), but not OVCAR3...
Keywords: | 2-[1-(2-pyridinyl)ethylidene]hydrazide, 1-azetidinecarbothioic acid |
Application: | p53-R175 reactivator |
CAS | 71555-25-4 |
MW: | 234.3 D |
From 130.00€
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