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Item number: Cay13107-10

Pimecrolimus is a natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase). Presumably through these actions, it blocks the activation of T cells by allogeneic dendritic cells (IC50 = 0.55 nM) without affecting dendritic cells. Moreover,...

Keywords:	Elidel, SDZ-ASM 981,...
Application:	Calcineurin inhibitor
CAS	137071-32-0
MW:	810.5 D

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