12 products were found matching "Cay13650"!

13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is an inactive metabolite of PGE1 (Cay-13010). It only weakly inhibits ADP-induced platelet aggregation in isolated human platelet-rich plasma (IC50 = 14.8 µg/ml) compared with PGE1.Formal Name: 11alpha-hydroxy-9,15-dioxo-prostan-1-oic acid. CAS Number: 5094-14-4....

Phencyclidine (PCP), known more commonly as angel dust, is a psychoactive drug that is regulated as a schedule I compound in the United States. 4-methoxy PCP is an analog of PCP which has recently been commercially produced as a designer drug. It preferentially binds the sigma-2 receptor (Ki = 143 nM) and less...

(1R,3R)-3-Benzoic acid 3-carboxycyclopentyl ester is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: (1R,3R)-3-(benzoyloxy)cyclopentanecarboxylic acid. Molecular Formula: C13H14O4. Formula Weight: 234.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. SMILES:...

CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene alpha (Gro-alpha, CXCL1). IL-8 and Gro-alpha are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB...

Oleoyl serinol is an analog of ceramide and an agonist of the cannabinoid receptor GPR119 that has an EC50 value of 12 µM for stimulating secretion of GLP-1 in mouse endocrine GLUTag cells. It has been found in E. coli that express human microbiota N-acyl synthase (hmNAS) genes. It induces cell death of F-11 murine...

Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively). It poorly inhibits neuropathy...

The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin. ZM 447439 is a selective inhibitor of Aurora B kinase (IC50 = 50 nM), less potently inhibiting Aurora C and A...

WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of phosphatidylinositol 3-kinase alpha (IC50 = 1,026 nM) and other kinases. WYE-354 induces G1 cell cycle arrest in both rapamycin-sensitive and...

Monoacylglycerol lipase (MAGL) hydrolyzes the endogenous cannabinoid 2-arachidonoyl glycerol (2-AG), terminating its capacity to activate cannabinoid receptors. Pristimerin is a naturally occurring terpenoid that potently inhibits MAGL (IC50 = 93 nM). Its actions are rapid, reversible, and noncompetitive....

ABT-869 is a dual VEGFR and PDGFR family kinase inhibitor (IC50s = 0.003, 0.004, 0.004, 0.19, 0.066, 0.003, and 0.014 µM for VEGFR1, VEGFR2, FLT3, VEGFR3, PDGFRbeta, CSF-1R, and KIT, respectively). It is selective for these kinases over other tyrosine kinases, including RET, FGFR, Src, EGFR, and c-Met (IC50s = 1.9,...

(±)-Clopidogrel is a racemic mixture of (R)-(-)- clopidogrel and the prodrug form of the active metabolite of clopidogrel (S)-(+)-clopidogrel (Cay-21002).Formal Name: alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetic acid, methyl ester, monohydrochloride. CAS Number: 130209-90-4. Molecular...

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kgamma (IC50 = 70 nM), compared to PI3Kalpha (IC50 = 240 nM),...