- Search results for Cay13634-%25
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9 products were found matching "Cay13634-%25"!
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Item number: Cay13643-25
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin) and regulate different pathways. PP242 is an inhibitor of the active site of mTOR kinase in...
Keywords: | 2-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol |
Application: | mTOR kinase inhibitor |
CAS | 1092351-67-1 |
MW: | 308.3 D |
From 43.00€
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Item number: Cay13636-25
JWH 398 (Cay-13636) is an analytical reference standard categorized as a synthetic cannabinoid. JWH 398 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.Formal Name: (4-chloro-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-methanone. CAS Number:...
Keywords: | (4-chloro-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-methanone |
Application: | Analytical reference standard, synthetic cannabinoid |
CAS | 1292765-18-4 |
MW: | 375.9 D |
From 241.00€
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Item number: Cay13639-25
The CXC chemokine receptor-4 (CXCR4) is a G protein-coupled receptor that is specific for stromal cell-derived factor-1 (SDF-1/ CXCL12). Activation of CXCR4 promotes homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types. Moreover, CXCR4...
Keywords: | N1,N4-di-2-pyridinyl-1,4-benzenedimethanamine |
Application: | CXCR4 antagonist |
CAS | 55778-02-4 |
MW: | 290.4 D |
From 26.00€
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Item number: Cay13346-5
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30...
Keywords: | AY 22989, NSC 226080, Wy 090217,... |
Application: | mTORC1 blocking |
CAS | 53123-88-9 |
MW: | 914.2 D |
From 50.00€
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Item number: Cay13614-25
GW 856553X is a dual inhibitor of p38alpha and p38beta MAPK (Kis = 0.0079 and 0.025 µM, respectively, in cell-free assays). It is selective for p38alpha and p38beta MAPK over p38gamma and p38delta MAPK when used at a concentration of 10 µM. GW 856553X inhibits LPS-induced TNF-alpha production in isolated rat and...
Keywords: | GSK-AHAB, SB 856553, 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide |
Application: | p38 MAPK inhibitor |
CAS | 585543-15-3 |
MW: | 383.5 D |
From 46.00€
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Item number: Cay13694-25
Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1 = 3 nM, Kd2 = 278 nM) to stabilize the TTR dimer-dimer interface and inhibit tetrameric dissociation. Tafamidis stabilizes wild-type and clinically...
Keywords: | PF-06291826, 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylic acid |
Application: | TTR kinetic stabilizer, Amyloidogenesis suppressant |
CAS | 594839-88-0 |
MW: | 308.1 D |
From 90.00€
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Item number: Cay13604-25
WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of phosphatidylinositol 3-kinase alpha (IC50 = 1,026 nM) and other kinases. WYE-354 induces G1 cell cycle arrest in both rapamycin-sensitive and...
Keywords: | 4-[6-[4-[(methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid,... |
Application: | mTOR inhibitor |
CAS | 1062169-56-5 |
MW: | 495.5 D |
From 125.00€
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Item number: Cay13624-25
Icariin is a prenylated flavonoid that has been found in E. pubescens and has diverse biological activities. It induces the differentiation of ES-D3 embryonic stem cells into cardiomyocytes when used at concentrations of 10 and 100 µM. Icariin (10 µM) increases the mRNA expression of RUNX family transcription factor...
Keywords: | 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-y... |
Application: | PDE5 inhibitor, Metabolic studies |
CAS | 489-32-7 |
MW: | 676.6 D |
From 102.00€
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Item number: Cay16343-25
Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations. It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7alpha-hydroxylase, regulating both xenobiotic and...
Keywords: | PCN, Pregnenolone 16alpha-carbonitrile, SC-4674, 3beta-hydroxy-20-oxo-pregn-5-ene-16alpha-carbonitrile |
Application: | Rodent pregnane X receptor (PXR) agonist |
CAS | 1434-54-4 |
MW: | 341.5 D |
From 54.00€
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