- Search results for Cay13503
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17 products were found matching "Cay13503"!
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Item number: Cay13353-500
Lignoceric acid is a 24-carbon saturated (24:0) fatty acid. In mammals, it is synthesized during brain development and is found in cerebrosides. The deficient peroxisomal oxidation of very-long-chain fatty acids, including lignoceric acid, contributes to certain syndromes, including Zellweger cerebro-hepato-renal...
Keywords: | C24:0, tetracosanoic acid |
Application: | Bioactive lipid assays |
CAS | 557-59-5 |
MW: | 368.6 D |
From 24.00€
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Item number: Cay13823-500
The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes. AX 048 is a potent group IVA cPLA2 inhibitor that demonstrates 50%...
Keywords: | 4-[(1,2-dioxohexadecyl)amino]-butanoic acid, ethyl ester |
Application: | cPLA2 inhibitor |
CAS | 873079-69-7 |
MW: | 383.6 D |
From 189.00€
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Item number: Cay13833-500
trans-Resveratrol-4'-O-D-glucuronide is a phase II metabolite of the antioxidant trans-resveratrol (Cay-70675). trans-Resveratrol-4'-O-D-glucuronide is formed via glucuronidation of trans-resveratrol by the UDP-glucuronosyltransferase (UGT) isoform UGT1A9.Formal Name:...
Keywords: | trans-R4'G, 4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]phenyl-beta-D-glucopyranosiduronic acid |
Application: | Metabolic studies |
CAS | 387372-20-5 |
MW: | 404.4 D |
From 196.00€
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Item number: Cay13003-500
2-Pyridylamide oxime is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: N-hydroxy-2-pyridinecarboximidamide. CAS Number: 1772-01-6. Synonyms: Picolinic Acid Amidoxime. Molecular Formula: C6H7N3O. Formula Weight: 137.1. Purity: >98%. Formulation: (Request formulation change), A crystalline...
Keywords: | Picolinic Acid Amidoxime, N-hydroxy-2-pyridinecarboximidamide |
Application: | Synthetic intermediate, Pharmaceutical synthesis |
CAS | 1772-01-6 |
MW: | 137.1 D |
From 22.00€
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Item number: Cay13623-500
Topiramate is a sugar sulfamate with anticonvulsant activity. It inhibits carbonic anhydrase in intact human erythrocytes (Ki = ~200 µM), as well as blocks sodium and calcium channels and kainate-induced currents in vitro. It also increases GABAA receptor-mediated chloride ion flux. Topiramate inhibits hind-limb...
Keywords: | McN 4853, RWJ 17021, TPM, 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose, 1-sulfamate |
Application: | Anticonvulsant |
CAS | 97240-79-4 |
MW: | 339.4 D |
From 85.00€
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Item number: Cay13673-500
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2alpha and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM)....
Keywords: | [[4-[5R-chloro-2Z-[3R-cyclohexyl-3S-hydroxy-1R-propenyl]-3S-hydroxycyclopentyl]-2R-butenyl]oxy]-acetic acid, isopropyl ester |
Application: | DP-agonist |
CAS | 154927-31-8 |
MW: | 429 D |
From 279.00€
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Item number: Cay13883-500
Prostaglandin F2alpha-1-glyceryl ester-d5 (PGF2alpha-1-glyceryl ester-d5) is intended for use as an internal standard for the quantification of PGF2alpha-1-glyceryl ester by GC- or LC-MS. 2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid...
Keywords: | PGF2alpha-1-glyceryl ester-d5, 9alpha,11alpha,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid, 1-glyceryl ester-d5 |
Application: | Bioactive Lipid Assays |
MW: | 433.6 D |
From 84.00€
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Item number: Cay13183-500
Phosphodiesterases (PDE) enzymatically convert the cyclic nucleotide second messengers cAMP and cGMP to 5'-AMP and 5'-GMP, respectively, thus terminating signal transduction. The cAMP-specific PDE4 isoforms may be particularly important in certain respiratory and neurological diseases. CP 80,633 is a selective...
Keywords: | 5-[3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-methoxyphenyl]tetrahydro-2-(1H)-pyrimidinone |
Application: | PDE4 inhibitor |
CAS | 135637-46-6 |
MW: | 316.4 D |
From 38.00€
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Item number: Cay13233-500
2,4-Dimethylthiazole-5-carboxylic acid is a highly functionalized and biased thiazole used for drug discovery. It is used as a heterocyclic building block to specifically modify lead compounds.Formal Name: 2,4-dimethyl-5-thiazolecarboxylic acid. CAS Number: 53137-27-2. Molecular Formula: C6H7NO2S. Formula Weight:...
Keywords: | 2,4-dimethyl-5-thiazolecarboxylic acid |
Application: | Drug discovery, Building block |
CAS | 53137-27-2 |
MW: | 157.2 D |
From 22.00€
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Item number: Cay13813-500
Axitinib is a VEGFR inhibitor (IC50s = 1.2, 0.25, and 0.29 nM for VEGFR1, -2, and -3, respectively). It also inhibits c-Kit and PDGFRbeta (IC50s = 1.7 and 1.6 nM, respectively). It inhibits VEGF-induced migration of and tube formation by human umbilical vein endothelial cells (HUVECs). Axitinib (1-100 mg/kg) reduces...
Keywords: | AG-013736, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide |
Application: | Tyrosine kinase inhibitor |
CAS | 319460-85-0 |
MW: | 386.5 D |
From 104.00€
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Item number: Cay13263-500
AA-861 is an inhibitor of 5-lipoxygenase (5-LO, IC50 = 0.8 µM). It is greater than 100-fold selective for 5-LO over 12-LO and cyclooxygenase (COX). AA-861 inhibits the production of 5-HETE and leukotriene B4 (LTB4, Cay-20110, Cay-10007240) induced by A23187 (Cay-22030) with IC50 values of 0.03 and 0.08 µM,...
Keywords: | A-61589, Docebenone, 2-(12-hydroxy-5,10-dodecadiyn-1-yl)-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione |
Application: | 5-LO inhibitor |
CAS | 80809-81-0 |
MW: | 326.4 D |
From 222.00€
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Item number: Cay13530-1
Bicyclo Prostaglandin E1 (bicyclo PGE1) is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. 13,14-dihydro-15-keto PGE1 itself is a metabolite of PGE1 found in human plasma at a median level of 10 pg/ml. Due to the inherent instability of 13,14-dihydro-15-keto PGE1,...
Keywords: | Bicyclo PGE1, 11-deoxy-13,14-dihydro-15-keto-11beta,16.xi.-cycloprostaglandin E1 |
Application: | Bioactive lipid assays |
CAS | 1283861-32-4 |
MW: | 336.5 D |
From 117.00€
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