7 products were found matching "Cay13499-%25"!

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MK2 Inhibitor IV
MK2 Inhibitor IV

Item number: Cay14399-5

Activation of the p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2) pathway has been implicated in promoting pro-inflammatory cytokine production and related inflammatory diseases. MK2 inhibitor IV is a highly selective, non-ATP competitive MK2 inhibitor with an IC50 value of 0.11 µM....
Keywords: MK 25, 5-(4-chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-2-furancarboxamide, monohydrochloride
Application: MK2 inhibitor
CAS 1314118-94-9
MW: 509.4 D
From 109.00€ *
Review
Suc-AAPF-pNA
Suc-AAPF-pNA

Item number: Cay14993-25

Suc-AAPF-pNA is a chromogenic substrate that can be cleaved by cathepsin G (Km = 1.7 mM), subtilisins, chymotrypsin (Km = 60 µM), chymase (Km = 4 mM), and cyclophilin, but not neutrophil elastase. Release of p-nitroanilide is monitored at 405-410 nm. This substrate can be used for inhibitor screening and kinetic...
Keywords: Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide,...
Application: Chromogenic substrate, Inhibitor screening, Kinetic analyses
CAS 70967-97-4
MW: 624.7 D
From 61.00€ *
Review
Rabeprazole (sodium salt)
Rabeprazole (sodium salt)

Item number: Cay14939-25

Rabeprazole is a proton pump inhibitor that selectively and irreversibly inhibits the gastric H+/K+ ATPase (IC50 = 72 nM). It can be activated more rapidly and over a greater pH range than other proton pump inhibitors such as omeprazole (Cay-14880), lansoprazole (Cay-13627), and pantoprazole (Cay-21345). Rabeprazole...
Keywords: E 3810, LY307640, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole, monosodium salt
Application: Proton pump inhibitor
CAS 117976-90-6
MW: 381.4 D
From 43.00€ *
Review
Xanthine
Xanthine

Item number: Cay31499-25

Xanthine is a purine base and intermediate in the biosynthesis of uric acid (Cay-16219). It is formed during mammalian purine catabolism in the liver via oxidation of hypoxanthine (Cay-22254) by xanthine oxidase (XO), which also oxidizes xanthine to produce uric acid. Xanthine is also formed from guanine,...
Keywords: 2,6-Dihydroxypurine, NSC 14664, 3,9-dihydro-1H-purine-2,6-dione
Application: Purine base, Uric acid biosynthesis intermediate
CAS 69-89-6
MW: 152.1 D
From 44.00€ *
Review
NSC 668036
NSC 668036

Item number: Cay23499-25

NSC 668036 is an inhibitor of the Dishevelled (Dvl) protein PDZ domain (Kd = 240 µM for mouse Dvl1 PDZ domain). NSC 668036 interacts with Dvl PDZ at the same binding site as Dapper and Frizzled, native binding partners in the Wnt signaling pathway. NSC 668036 (180 ng) reduces expression of the Wnt target gene,...
Keywords: N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine, (1S)-1-carboxy-2-methylpropyl ester
Application: Dishevelled PDZ domain inhibitor
CAS 144678-63-7
MW: 460.5 D
From 50.00€ *
Review
Bisindolylmaleimide IV
Bisindolylmaleimide IV

Item number: Cay13299-25

Bisindolylmaleimide IV (BIM IV) is a cell permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 µM. BIM IV was designed to be more discriminative than its parent compound, the non-selective PKC inhibitor, staurosporine (Cay-81590). However, BIM IV also inhibits protein...
Keywords: Arcyriarubin A, BIM IV, 3,4-di-1H-indol-3-yl-1H-pyrrole-2,5-dione
Application: PKC inhibitor
CAS 119139-23-0
MW: 327.3 D
From 72.00€ *
Review
CAY10499
CAY10499

Item number: Cay10007875-25

CAY10499 is a non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively). It also inhibits ATGL, DAGLa, ABHD6, and CES1 by 95, 60, 90, and 95%, respectively, when used at a concentration of 5 mM. CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and...
Keywords: [4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-carbamic acid, phenylmethyl ester
Application: HSL inhibitor
CAS 359714-55-9
MW: 355.3 D
From 22.00€ *
Review