3 products were found matching "Cay13496-%25"!
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Tafamidis
Item number: Cay13694-25
Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1 = 3 nM, Kd2 = 278 nM) to stabilize the TTR dimer-dimer interface and inhibit tetrameric dissociation. Tafamidis stabilizes wild-type and clinically...
| Keywords: | PF-06291826, 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylic acid |
| Application: | TTR kinetic stabilizer, Amyloidogenesis suppressant |
| CAS | 594839-88-0 |
| MW: | 308.1 D |
From 90.00€
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CX-516
Item number: Cay14936-25
CX-516 is an AMPA receptor modulator. It increases the mean open time of AMPA receptors which increases the amplitude of trisynaptic responses to presynaptic stimulation in rat hippocampal slices. In vivo, CX-516 (10-50 mg/kg) accelerates acquisition of a conditioned fear response in rats in a dose-dependent manner....
| Keywords: | Ampalex, BDP-12, Benzoyl-Piperidine-12, 1-piperidinyl-6-quinoxalinyl-methanone |
| Application: | AMPA modulator |
| CAS | 154235-83-3 |
| MW: | 241.3 D |
From 68.00€
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ACT-373898
Item number: Cay34916-5
ACT-373898 is a metabolite of the endothelin (ET) receptor type A (ETA) and ETB dual antagonist macitentan (Cay-23304).Formal Name: 2-[[5-(4-bromophenyl)-6-[[(propylamino)sulfonyl]amino]-4-pyrimidinyl]oxy]-acetic acid. CAS Number: 1433875-14-9. Molecular Formula: C15H17BrN4O5S. Formula Weight: 445.3. Purity: >90%....
| Keywords: | 2-[[5-(4-bromophenyl)-6-[[(propylamino)sulfonyl]amino]-4-pyrimidinyl]oxy]-acetic acid |
| Application: | Macitentan metabolite |
| CAS | 1433875-14-9 |
| MW: | 445.3 D |
From 50.00€
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