10 products were found matching "Cay13486-%25"!

Alfuzosin is a post-synaptic alpha1-adrenergic receptor antagonist commonly used to improve lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH). It displays high-affinity with non-selectivity for the three known human alpha1 adrenoceptors (pKi = 8.0, 8.0, and 8.5 for alpha1A, alpha1B, and...

Apurinic/apyrimidinic endonuclease-1 (Ape-1) is involved in base excision repair, cleaving the phosphodiester linkage that is 5' to the abasic site to produce a single strand break. DNA base excision repair pathway inhibitor is a cell-permeable inhibitor of Ape-1 (IC50 = 3-11 µM). Although not toxic to cells by...

Antide is a third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It inhibits GnRH-induced secretion of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and gonadotropin in isolated rat pituitary cells when used at concentrations ranging from 0.001 to 1,000 nM but does not induce...

Maropitant is an neurokinin-1 (NK1) receptor antagonist. It reduces motion sickness- or doxorubicin-induced emesis in dogs. Formulations containing maropitant have been used as antiemetics in dogs.Formal Name:...

(±)-Blebbistatin is a racemic mixture of (-)-blebbistatin (Cay-13013) and (+)-blebbistatin (Cay-13165), the active and inactive forms, respectively. (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in...

alpha-Ethyltryptamine (AET), like alpha-methyltryptamine (Cay-11135), is a psychedelic drug with schedule 1 status in the United States. Both alter monoamine release and re-uptake in the brain. 4-methyl-alpha-Ethyltryptamine (Cay-13886) is a homolog of AET. Its physiological and toxicological properties remain to be...

Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is active against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s = 0.015-2.0 mg/l)....

Chidamide is an inhibitor of histone deacetylases (HDACs, IC50s = 0.095, 0.160, 0.067, 0.733, 0.078, and 0.432 µM for HDAC1-3, 8, 10, and 11, respectively). It is selective for these HDACs over HDAC4-7 and 9 (IC50s = >30 µM for all). Chidamide also inhibits nicotinamide phosphoribosyltransferase (Nampt, IC50 = 2.1...

Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of...

Protein function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first...