10 products were found matching "Cay13483-%25"!

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response. Resolvin D3 (RvD3) is a DHA-derived product first identified in...

Protein function: A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15373842, PubMed:15764715, PubMed:20702771, PubMed:19965576, PubMed:21490593,...

Eicosapentaenoic acid (EPA, Cay-90110) is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE (Cay-10467) is a possible metabolite produced from EPA following epoxidation of the alpha-5 double bond. (±)5(6)-DiHETE...

12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-gamma-linolenic acid (DGLA). 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 µM), alpha granule secretion, integrin alphaIIbbeta3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.Formal Name:...

Zinc protoporphyrin-9 (ZnPPIX) is an endogenous metabolite formed during heme biosynthesis under conditions of iron insufficiency or impaired iron utilization. It also regulates heme catabolism through competitive inhibition of heme oxygenase, the rate-limiting enzyme in the heme degradation pathway that produces...

Nepsilon-(1-Carboxymethyl)-L-lysine (CML) is an advanced glycation end product (AGE), produced by the oxidative modification of glycated proteins during oxidative stress. Levels of CML increase with aging and during diabetes, cancer, vascular disease, and other pathologies marked by oxidative stress. CML activates...

Prostaglandin F2alpha-1-glyceryl ester-d5 (PGF2alpha-1-glyceryl ester-d5) is intended for use as an internal standard for the quantification of PGF2alpha-1-glyceryl ester by GC- or LC-MS. 2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid...

Microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE2 (Cay-14010) and leukotrienes (LTs), respectively. PGE2 and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer. Pirinixic acid...

WB 1:500 - 1:2000, IHC 1:50 - 1:200. Protein function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation,...

AZD 7986 is a reversible and covalent inhibitor of dipeptidyl peptidase 1 (DPP-1), also known as cathepsin C (IC50 = 3.9 nM). It is selective for DPP-1 over cathepsins S, -L, -B, -K, -D, -E, -Z, -H, and -G (IC50s = >20 µM for all), as well as a panel of greater than 200 enzymes, receptors, ion channels, and...