- Search results for Cay13482-%25
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16 products were found matching "Cay13482-%25"!
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Item number: Cay13284-25
MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 µM). However, it does not inhibit HDAC8 (IC50 > 100 µM). MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in...
Keywords: | Entinostat, SNDX 275, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-carbamic acid, 3-pyridinylmethyl ester |
Application: | HDAC inhibitor |
CAS | 209783-80-2 |
MW: | 376.4 D |
From 28.00€
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Item number: Cay13884-25
Puromycin is a derivative of the glomerular epithelial cell toxin puromycin aminonucleoside (Cay-15509) and an inhibitor of protein synthesis that has been found in S. alboniger. Puromycin is structurally similar to the amino acid-bearing end of tRNA, which allows it to enter the ribosome during protein synthesis,...
Keywords: | CL 13,900, CL 16,536, NSC 3055, PDH, 3'-[[2S-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine,... |
Application: | Aminonucleosid antibiotic |
CAS | 58-58-2 |
MW: | 544.4 D |
From 50.00€
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Item number: Cay13084-25
STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice. STF-62247...
Keywords: | N-(3-methylphenyl)-4-(4-pyridinyl)-2-thiazolamine |
Application: | Autophagy inducer |
CAS | 315702-99-9 |
MW: | 267.3 D |
From 81.00€
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Item number: Cay13184-25
Equol is a nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora. The estrogen receptor (ER) binding activity of the naturally occurring (S)-enantiomer demonstrates greater affinity toward ERbeta while the (R)-enantiomer demonstrates greater...
Keywords: | 3,4-dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol |
Application: | Estrogen receptor agonist |
CAS | 94105-90-5 |
MW: | 242.3 D |
From 44.00€
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Item number: Cay13248-25
L-DOPA is a metabolic precursor of dopamine that is capable of crossing the blood-brain barrier. It is produced from L-tyrosine by tyrosine hydroxylase and metabolized by catechol-O-methyl transferase (COMT). In the brain L-DOPA is converted to dopamine. Formulations containing L-DOPA have been used in stroke...
Keywords: | 3,4-Dihydroxyphenylalanine, Levodopa, 3-hydroxy-L-tyrosine |
Application: | Neuropharmacological agent |
CAS | 59-92-7 |
MW: | 197.2 D |
From 26.00€
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Item number: Cay21348-25
Davercin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It has broad-spectrum activity against various Gram-positive and Gram-negative bacteria (MICs = 0.02-50 µg/ml). Davercin is non-toxic to mice...
Keywords: | Erythromycin cyclocarbonate, cyclic 11,12-carbonate erythromycin |
Application: | Semi-synthetic antibacterial macrolide antibiotic, protein synthesis inhibitor |
CAS | 55224-05-0 |
MW: | 759.9 D |
From 90.00€
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Item number: Cay14438-25
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1, IC50 = 0.39 µM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound...
Keywords: | 1,5-Dihydroxyisoquinoline, NSC 65585, 5-hydroxy-1(2H)-isoquinolinone |
Application: | PARP1 inhibitor |
CAS | 5154-02-9 |
MW: | 161.2 D |
From 48.00€
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Item number: Cay15438-25
bpV(HOpic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 14 nM). It also inhibits the vascular endothelial PTP, PTP-beta (IC50 = 4.9 µM), and PTP-1betaB (IC50 = 25.3 µM). At 15 µM, bpV(HOpic) has been shown to protect...
Keywords: | Bisperoxovanadium(HOpic), (5-hydroxy-2-pyridinecarboxylato-kappaN1,kappaO2)oxodiperoxy-vanadate(2-), dipotassium |
Application: | PTEN inhibitor |
CAS | 722494-26-0 |
MW: | 347.2 D |
From 60.00€
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Item number: Cay14832-25
Ibudilast is an inhibitor of phosphodiesterase 4 (PDE4, IC50s = 54, 65, 239, and 166 nM for PDE4A-D, respectively). It is selective for PDE4 over PDE1, PDE7A, PDE7B, and PDE9A (IC50s = >10,000 nM for all) but does inhibit PDE3A, PDE3B, and PDE5A (IC50s = 1,600, 2,700, and 3,510 nM, respectively). Ibudilast inhibits...
Keywords: | AV 411, KC-404, 2-methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone |
Application: | PDE4 inhibitor |
CAS | 50847-11-5 |
MW: | 230.3 D |
From 60.00€
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Item number: Cay10348-25
Sphingosine kinase (SPHK) is an important enzyme in the sphingolipid metabolic pathway. SPHKs phosphorylate D-erythro-sphingosine to yield sphingosine-1-phosphate (S1P). To date two isoforms of SPHK, SPHK1 and SPHK2, have been identified & characterized from mammalian cells. Among them, SPHK1 has been implicated to...
Keywords: | SK 1, SK 1, SPK 1, SPK 1, Sphingosine kinase 1, Sphingosine kinase 1, Acetyltransferase SPHK1, Acetyltransferase SPHK1 |
Application: | Enzyme activity |
MW: | 47,5 kD |
571.00€
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Item number: Cay18348-25
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 µM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases...
Keywords: | N-methyl-4-(phenylmethoxy)-1-piperidineethanamine, dihydrochloride |
Application: | PRMT4 inhibitor, PRMT6 inhibitor |
CAS | 2095432-59-8 |
MW: | 321.3 D |
From 60.00€
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Item number: Cay13648-25
Alfuzosin is a post-synaptic alpha1-adrenergic receptor antagonist commonly used to improve lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH). It displays high-affinity with non-selectivity for the three known human alpha1 adrenoceptors (pKi = 8.0, 8.0, and 8.5 for alpha1A, alpha1B, and...
Keywords: | SL 77499-10, Uroxatral, N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide,... |
Application: | alpha1-adrenergic receptor antagonist |
CAS | 81403-68-1 |
MW: | 425.9 D |
From 60.00€
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