10 products were found matching "Cay13480"!

Puromycin is a derivative of the glomerular epithelial cell toxin puromycin aminonucleoside (Cay-15509) and an inhibitor of protein synthesis that has been found in S. alboniger. Puromycin is structurally similar to the amino acid-bearing end of tRNA, which allows it to enter the ribosome during protein synthesis,...

Equol is a nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora. The estrogen receptor (ER) binding activity of the naturally occurring (S)-enantiomer demonstrates greater affinity toward ERbeta while the (R)-enantiomer demonstrates greater...

MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 µM). However, it does not inhibit HDAC8 (IC50 > 100 µM). MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in...

5-(2-Aminopyridyl)amide oxime is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: 6-amino-N-hydroxy-3-pyridinecarboximidamide. CAS Number: 468068-28-2. Molecular Formula: C6H8N4O. Formula Weight: 152.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility:...

STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice. STF-62247...

Erlotinib is an EGFR inhibitor (Ki = 2.7 nM). It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM. Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM. Erlotinib (25 mg/kg) reduces EGF-induced EGFR...

Zinc protoporphyrin-9 (ZnPPIX) is an endogenous metabolite formed during heme biosynthesis under conditions of iron insufficiency or impaired iron utilization. It also regulates heme catabolism through competitive inhibition of heme oxygenase, the rate-limiting enzyme in the heme degradation pathway that produces...

PKCtheta pseudosubstrate inhibitor is a synthetic peptide that corresponds to amino acid residues of the pseudosubstrate domain of protein kinase Ctheta (PKCtheta). It selectively, reversibly, and substrate-competitively inhibits PKCtheta activity and, thus, is used to delineate the signaling functions of PKCtheta,...

12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-gamma-linolenic acid (DGLA). 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 µM), alpha granule secretion, integrin alphaIIbbeta3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.Formal Name:...

The eicosapentaenoic acid (EPA) Quant-PAK has been designed for the convenient, precise quantification of EPA by GC- or LC-MS. It includes a 50 µg vial of EPA-d5 and a precisely weighed vial of unlabeled EPA, with the precise weight (2-4 mg) indicated on the vial. This unlabeled EPA can be used to quantify the...