Timolol is a non-selective beta-adrenergic receptor antagonist with log Kd values of -8.27, -9.86, and -6.8 for binding to human beta1-, beta2-, and beta3-adrenoceptors, respectively. It has been reported that only the (S) enantiomer contributes to the beta-blocking effects of racemic timolol, but the weakly active...

CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria. It displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 µM against S. aureus RN4220, P. aeruginosa PAO1, E....