- Search results for Cay13365
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17 products were found matching "Cay13365"!
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Item number: Cay13336-5
CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene alpha (Gro-alpha, CXCL1). IL-8 and Gro-alpha are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB...
Keywords: | N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-urea |
Application: | CXCR2 antagonist |
CAS | 182498-32-4 |
MW: | 352.1 D |
From 110.00€
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Item number: Cay11136-5
Phencyclidine (PCP), known more commonly as angel dust, is a psychoactive drug that is regulated as a schedule I compound in the United States. 4-methoxy PCP is an analog of PCP which has recently been commercially produced as a designer drug. It preferentially binds the sigma-2 receptor (Ki = 143 nM) and less...
Keywords: | 4-MeO PCP, 4-MeO Phencyclidine, Methoxydine, 1-[1-(4-methoxyphenyl)cyclohexyl]-piperidine, monohydrochloride |
Application: | Analytical reference standard, PCP analog, Designer drug |
CAS | 2185-93-5 |
MW: | 309.9 D |
From 291.00€
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Item number: Cay13665-1
Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of...
Keywords: | 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-octanoic acid |
Application: | mPGES-1/5-LO inhibitor |
CAS | 916482-17-2 |
MW: | 408 D |
From 74.00€
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Item number: Cay11365-50
(1S,3R)-3-Benzoic acid 3-carboxycyclopentyl ester is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: (1S,3R)-3-(benzoyloxy)cyclopentanecarboxylic acid. Molecular Formula: C13H14O4. Formula Weight: 234.3. Purity: >95%. Formulation: (Request formulation change), A neat oil. SMILES:...
Keywords: | (1S,3R)-3-(benzoyloxy)cyclopentanecarboxylic acid |
Application: | Synthetic intermediate |
MW: | 234.3 D |
114.00€
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Item number: Cay13655-500
Adapalene is a synthetic retinoid and an agonist of retinoic acid receptors (RARs, Kds = 1,100, 34, and 130 nM for RARalpha, RARbeta, and RARgamma, respectively). It inhibits growth and differentiation of sebocytes in a concentration-dependent manner in primary rat preputial cell culture. Adapalene (10 µM)...
Keywords: | CD 271, 6-(4-methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid |
Application: | Retinoic acid receptor agonist |
CAS | 106685-40-9 |
MW: | 412.5 D |
From 226.00€
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Item number: Cay13368-5
Piroxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 (TXB2, Cay-19030) from arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in HEL human erythroleukemic cells (IC50 = 0.45 µM), which...
Keywords: | NSC 666076, 4-hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide |
Application: | COX inhibitor |
CAS | 36322-90-4 |
MW: | 331.4 D |
From 27.00€
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Item number: Cay13360-5
Isoprostanes are a family of prostanoid molecules of non-cyclooxygenase origin. 8-iso Prostaglandin E1 (8-iso PGE1) is an isoprostane which is found in human semen at levels of 7 µg/ml. It is a pulmonary vasoconstrictor in anesthetized dogs with a potency similar to PGF2alpha.Formal Name:...
Keywords: | 8-epi PGE1, 8-iso PGE1, Ovinonic acid, 9-oxo-11alpha,15S-dihydroxy-(8beta)-prost-13E-en-1-oic acid |
Application: | Bioactive lipid assays |
CAS | 21003-46-3 |
MW: | 354.5 D |
From 69.00€
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Item number: Cay13369-25
Prostaglandin E2 (PGE2), one of the most widely investigated PGs, can be used as a biomarker of inflammation, disease state, or therapeutic effectiveness. However due to its rapid metabolism, direct measurement of PGE2 in biological samples is difficult. The major urinary metabolite of PGE2, tetranor-PGEM, serves as...
Keywords: | tetranor-Prostaglandin A Metabolite, 5R-(2-carboxyethyl)-epsilon,4-dioxo-2-cyclopentene-1S-octanoic acid |
Application: | Prostaglandin studies |
CAS | 52510-53-9 |
MW: | 310.3 D |
From 164.00€
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Item number: Cay13363-25
Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle. tetranor-PGDM is an abundant urinary metabolite of PGD2 that is detectable both in...
Keywords: | tetranor-PGJ Metabolite, 8-((1R,2S)-2-(2-carboxyethyl)-5-oxocyclopent-3-en-1-yl)-6-oxooctanoic acid |
Application: | Lipid studies |
CAS | 1352751-83-7 |
MW: | 310.3 D |
From 196.00€
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Item number: Cay13367-25
(±)17(18)-EpETE methyl ester is an analog of the eicosapentaenoic acid (EPA) metabolite (±)17(18)-EpETE (Cay-50861) that is more lipid soluble.Formal Name: (±)17,18-epoxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid, methyl ester. CAS Number: 141339-46-0. Synonyms: (±)17,18-EEQ methyl ester, (±)17,18-epoxy Eicosatetraenoic...
Keywords: | (±)17,18-EEQ methyl ester, (±)17,18-epoxy Eicosatetraenoic Acid methyl ester,... |
Application: | More lipid soluble methyl ester |
CAS | 141339-46-0 |
MW: | 332.5 D |
From 65.00€
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Item number: Cay13346-5
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30...
Keywords: | AY 22989, NSC 226080, Wy 090217,... |
Application: | mTORC1 blocking |
CAS | 53123-88-9 |
MW: | 914.2 D |
From 50.00€
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Item number: Cay13326-5
Pifithrin-alpha is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. It prevents p53-mediated apoptosis induced by cytotoxic compounds in C8 cells at 10 µM and in human umbilical vein endothelial cells at 30 µM. Pifithrin-alpha can also protect cells from DNA damage-induced...
Keywords: | PFT-alpha, 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-ethanone, monohydrobromide |
Application: | p53 inactivator |
CAS | 63208-82-2 |
MW: | 367.3 D |
From 86.00€
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