- Search results for Cay13347-%25
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10 products were found matching "Cay13347-%25"!
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Item number: Cay13345-25
Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor. When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the...
Keywords: | (p-methoxyphenyl)morpholino-phosphinodithioic acid |
Application: | Hydrogen sulfide donor |
CAS | 106740-09-4 |
MW: | 377.5 D |
From 82.00€
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Item number: Cay13346-25
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30...
Keywords: | AY 22989, NSC 226080, Wy 090217,... |
Application: | mTORC1 blocking |
CAS | 53123-88-9 |
MW: | 914.2 D |
From 50.00€
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Item number: Cay13340-25
As a cofactor of more than 300 enzymes, zinc is integral for a wide variety of cellular processes that affect most biological functions. Most notably, its bioavailability is important to the regulation of apoptosis, cell proliferation, and differentiation. TPEN is a cell permeant metal ion chelator that is used in...
Keywords: | TPEDA, N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine |
Application: | Metal ion chelator |
CAS | 16858-02-9 |
MW: | 424.6 D |
From 23.00€
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Item number: Cay13342-25
SU 5416 is a tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR2, FLK1/KDR) and a suppressor of tumor vascularization, preventing the growth of multiple tumor types. In addition to inhibiting VEGFR2 (IC50 = 1 µM), SU 5416 also inhibits PDGFR (IC50 = 20 µM),...
Keywords: | NSC 696819, Semaxinib, Sugen 5416, VEGFR 2 Kinase Inhibitor,... |
Application: | Tyrosine kinase inhibitor |
CAS | 204005-46-9 |
MW: | 238.3 D |
From 164.00€
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Item number: Cay13344-25
Mitogen-activated protein kinases (MAPKs) mediate signal transduction from cell surface receptors to the nucleus and are classified into various subtypes. p38 MAPK is activated by environmental stresses and inflammatory cytokines and is critical for normal immune and inflammatory responses as it regulates the...
Keywords: | PB 203580, RWJ 64809, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-pyridine, monohydrochloride |
Application: | p38 MAPK inhibitor |
CAS | 869185-85-3 |
MW: | 413.9 D |
From 149.00€
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Item number: Cay13341-25
Transforming growth factor-beta (TGF-beta) signals through a cell surface heteromeric complex involving type I (TGF-beta RI) and type II (TGF-beta RII) receptors. Downstream signal transduction is mediated by the TGF-beta RI kinase domain through the phosphorylation of Smad proteins. LY364947 is a selective...
Keywords: | HTS 466284, TGF-beta RI Kinase Inhibitor, 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline |
Application: | TGFbetaRI inhibitor |
CAS | 396129-53-6 |
MW: | 272.3 D |
From 123.00€
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Item number: Cay13307-25
D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC, Ki = 6.4 µM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations...
Keywords: | Tricyclodecan-9-yl xanthogenate, O-(octahydro-4,7-methano-1H-inden-5-yl) ester, carbonodithioic acid, monopotassium salt |
Application: | PC-PLC inhibitor |
CAS | 83373-60-8 |
MW: | 266.5 D |
From 50.00€
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Item number: Cay13327-25
PPM-18 is a naphthoquinone compound that inhibits NF-kappaB activation in vitro and in vivo (IC50 = 5 µM). Through this action, it inhibits the expression of inducible nitric oxide synthase (iNOS) in macrophages treated with lipopolysaccharide and suppresses inflammation and sepsis.Formal Name:...
Keywords: | NSC 73233, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-benzamide |
Application: | NF-kappaB inhibitor |
CAS | 65240-86-0 |
MW: | 277.3 D |
From 26.00€
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Item number: Cay13337-25
ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor-alpha and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.Formal Name: 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(5-phenylthio)methyl]phenyl]-2-propenamide. CAS...
Keywords: | 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(5-phenylthio)methyl]phenyl]-2-propenamide |
Application: | Tyrosine kinase inhibitor |
CAS | 107761-24-0 |
MW: | 354.4 D |
From 52.00€
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Item number: Cay17334-25
Verteporfin is a photosensitizer used during photodynamic therapy to eliminate abnormal blood vessels in the eye that are associated with conditions such as macular degeneration. It accumulates in these abnormal blood vessels and, when activated by nonthermal red light with a wavelength of 693 nm in the presence of...
Keywords: | BPD-MA, CL 318,952,... |
CAS | 129497-78-5 |
MW: | 718.8 D |
From 43.00€
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