- Search results for Cay13345
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10 products were found matching "Cay13345"!
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Item number: Cay13345-100
Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor. When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the...
Keywords: | (p-methoxyphenyl)morpholino-phosphinodithioic acid |
Application: | Hydrogen sulfide donor |
CAS | 106740-09-4 |
MW: | 377.5 D |
From 82.00€
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Item number: Cay13334-5
Bisindolylmaleimide IX (BIM IX) is a potent, cell-permeable inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-alpha, PKC-betaI, PKC-betaII, PKC-gamma, and PKC-epsilon, respectively). It is a poor inhibitor of protein kinase A (PKA, IC50 = 0.9 µM) and calcium/calmodulin kinase II...
Keywords: | BIM IX, Ro 31-8220, carbamimidothioic acid,... |
Application: | PKC inhibitor |
CAS | 138489-18-6 |
MW: | 553.7 D |
From 60.00€
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Item number: Cay13344-5
Mitogen-activated protein kinases (MAPKs) mediate signal transduction from cell surface receptors to the nucleus and are classified into various subtypes. p38 MAPK is activated by environmental stresses and inflammatory cytokines and is critical for normal immune and inflammatory responses as it regulates the...
Keywords: | PB 203580, RWJ 64809, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-pyridine, monohydrochloride |
Application: | p38 MAPK inhibitor |
CAS | 869185-85-3 |
MW: | 413.9 D |
From 149.00€
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Item number: Cay11334-5
An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John's wort) and has antidepressant, antiviral, and anticancer activities. Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects. It exerts...
Keywords: | NSC 407313, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-phenanthro[1,10,9,8-opqra]perylene-7,14-dione |
Application: | St. John's wort component |
CAS | 548-04-9 |
MW: | 504.5 D |
From 34.00€
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Item number: Cay11345-5
Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels, as shown in patch clamp (Ki = 1.9 nM) and whole smooth muscle cell studies (Ki = 35.7 nM). It also enhances the binding of charybdotoxin (Cay-24115), a peptidyl neurotoxin, to BKCa...
Keywords: | 5,6,6a,7,12,12bS,12cR,13,14,14aS-decahydro-4bS-hydroxy-2R-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-1-benzopyrano[5',6... |
Application: | BKCa channel inhibitor |
CAS | 57186-25-1 |
MW: | 435.6 D |
From 61.00€
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Item number: Cay13455-1
Mouse anti-c-myc IgG clone 9E10 (EQKLISEEDL) conjugated to SureLight(TM) P3 Antibody: Mouse monoclonal anti-c-Myc IgG1 Dye: SureLight(TM) P3 Excitation max. lambda: 614 nm Emission max. lambda: 662 nm Clone: 9E10 (EQKLISEEDL) Isotype: IgG1 Uses: Flow cytometry, fluorescence-activated cell sorting, and protein...
Application: | FC, Fluorescence |
Host: | Mouse |
Species reactivity: | broad |
488.00€
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Item number: Cay13346-5
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30...
Keywords: | AY 22989, NSC 226080, Wy 090217,... |
Application: | mTORC1 blocking |
CAS | 53123-88-9 |
MW: | 914.2 D |
From 50.00€
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Item number: Cay13341-5
Transforming growth factor-beta (TGF-beta) signals through a cell surface heteromeric complex involving type I (TGF-beta RI) and type II (TGF-beta RII) receptors. Downstream signal transduction is mediated by the TGF-beta RI kinase domain through the phosphorylation of Smad proteins. LY364947 is a selective...
Keywords: | HTS 466284, TGF-beta RI Kinase Inhibitor, 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline |
Application: | TGFbetaRI inhibitor |
CAS | 396129-53-6 |
MW: | 272.3 D |
From 123.00€
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Item number: Cay13340-25
As a cofactor of more than 300 enzymes, zinc is integral for a wide variety of cellular processes that affect most biological functions. Most notably, its bioavailability is important to the regulation of apoptosis, cell proliferation, and differentiation. TPEN is a cell permeant metal ion chelator that is used in...
Keywords: | TPEDA, N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine |
Application: | Metal ion chelator |
CAS | 16858-02-9 |
MW: | 424.6 D |
From 23.00€
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Item number: Cay13342-25
SU 5416 is a tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR2, FLK1/KDR) and a suppressor of tumor vascularization, preventing the growth of multiple tumor types. In addition to inhibiting VEGFR2 (IC50 = 1 µM), SU 5416 also inhibits PDGFR (IC50 = 20 µM),...
Keywords: | NSC 696819, Semaxinib, Sugen 5416, VEGFR 2 Kinase Inhibitor,... |
Application: | Tyrosine kinase inhibitor |
CAS | 204005-46-9 |
MW: | 238.3 D |
From 164.00€
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